Registration Dossier
Registration Dossier
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EC number: 201-128-1 | CAS number: 78-63-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
BCF: potential for bioaccumulation
Acute dermal: penetrates skin, severely irritating to skin
28 and 90-day study: effects on liver and male kidneys
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
No substance specific data on metabolism and kinetics are available.
The registered substance is expected to be absorbed orally based on systemic effects noted in repeat dose studies.
10% dermal absorption is assumed based on molecular weight of 290.4, a log Pow of 7.34, water solubility of 131 μg/l and calculated vapor pressure of 0.00951 mm Hg (1.268 Pa) at 25 °C. Dermal absorption is expected to be low due to the low water solubility and high partition coefficient. Dermal irritation may enhance penetration.
The registered substance has a low vapor pressure. However any lipophilic compound may be taken up by micellular solubilisation but this
mechanism may be of particular importance for highly lipophilic compounds (log P >4), particularly those that are poorly soluble in water (1 mg/l or less). It is therefore assumed that some degree of absorption via inhalation will take place.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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