Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result:

BCF: potential for bioaccumulation

Acute dermal: penetrates skin, severely irritating to skin

28 and 90-day study: effects on liver and male kidneys

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
10
Absorption rate - inhalation (%):
100

Additional information

No substance specific data on metabolism and kinetics are available.

The registered substance is expected to be absorbed orally based on systemic effects noted in repeat dose studies.

10% dermal absorption is assumed based on molecular weight of 290.4, a log Pow of 7.34, water solubility of 131 μg/l and calculated vapor pressure of 0.00951 mm Hg (1.268 Pa) at 25 °C. Dermal absorption is expected to be low due to the low water solubility and high partition coefficient. Dermal irritation may enhance penetration.

The registered substance has a low vapor pressure. However any lipophilic compound may be taken up by micellular solubilisation but this

mechanism may be of particular importance for highly lipophilic compounds (log P >4), particularly those that are poorly soluble in water (1 mg/l or less). It is therefore assumed that some degree of absorption via inhalation will take place.