Registration Dossier

Administrative data

First-aid measures

Eyes :
Rinse the affected eye with widely spread lids for
10 minutes under running water whilst protecting
the unimpaired eye.
Arrange medical treatment.
Immediately remove contact lenses if these are being worn.

Skin :
Whilst protecting yourself, relocate the casualty away
from the source of danger.
Remove contaminated clothing while protecting yourself.
Immediate careful cleansing of the skin is most important.
Carefully wash contaminated skin areas repeatedly with soap
and water.
Intermittently wash with polyethylene glycol 400 (e.g.
Macrogol) if available, let it act for some minutes, then
thoroughly wash it off. Repeat the procedure several times.
Under no circumstances use alcohol, gasoline or other
solvents.
Lay the casualty down in a quiet place and protect him
against hypothermia.
Working clothes should also be changed following massive
contamination with vapors.
In every case, even if there are no symptoms yet and even
following only a little contamination, as soon as possible:
Arrange medical treatment.

Respiratory tract :
Whilst protecting yourself remove the casualty from the
hazardous area and take him to the fresh air.
Lay the casualty down in a quiet place and protect him
against hypothermia.
If available, have the casualty inhale oxygen, particularly
if dyspnoea is already noticeable.
For dyspnoea have the casualty take a semi-upright position,
if there is (danger of) unconsciousness a stable side
position.
Always call a physician to the site of the accident.
Poisoning symptoms can appear after a period of delay

Swallowing :
Rinse the mouth and spit the fluids out.
Apply charcoal (3 tablespoons as a suspension in a
glass of water).
or:
If the casualty is conscious have him drink copious
amounts of liquids (water).
Make the casualty vomit.
Under no circumstances apply cooking oil, castor oil,
milk or alcohol
During vomiting hold the head of the casualty low with the
body in a prone position in order to avoid aspiration.
Always call a physician to the site of the accident.
Poisoning symptoms can appear after a period of delay.

Information for physicians :
According to animal experiments, 2,4-dichloroaniline is an
efficient MetHb forming substance. The poisoning picture is
similar to that of aniline; analogous measures are to be
used for the therapy.
- Symptoms of acute poisoning:
Eyes: probably moderate to severe irritation (burning
sensation, reddening, swelling); possibly (after a delay)
lesions to the cornea
Skin: moderate local irritation but danger of absorptive-
toxic effects even following apparently insignificant
contact(!); allergic skin reactions not excluded
Inhalation: absorptive-toxic effects, possibly without any
warning through irritation
Ingestion: initially possibly only nausea but serious
absorptive-toxic effects even following low doses
Absorption: dependent on the dose/intake pathway, but
generally very rapid onset of methemoglobinemia: cyanosis
as early sign (initially noticeable on the lips and acral
parts); initially possibly also excitation; with increasing
MetHb level then increase of cyanosis, headache, vertigo,
vomiting, tachycardia, dyspnoea (frequently less pronounced
than would be expected from the degree of cyanosis); danger
of unconsciousness/coma, cramps, circulatory arrest; after
the acute phase possible hemolysis, functional disturbances
to the kidneys, icterus, consequences of hypoxia.
- Medical advice:
Following contamination of the eyes with the substance,
careful rinsing should be followed by ophthalmologic further
treatment.
Repeatedly wash contaminated skin with soap and water.
Polyethylene glycol 400 will probably be more effective to
clean the skin and to reduce absorption: apply it
repeatedly, let it act for a short time period, then wash
it off with soap and water.
Watch for contamination under the fingernails etc.
Hospitalize the casualty for detailed diagnosis of the
poisoning.
Following inhalation of vapors, immediate application of
oxygen is indicated, followed by a check in hospital.
Following ingestion, for primary elimination gastrolavage
under usual conditions should be carried out. Prolonged post
treatment with charcoal and sodium sulfate as laxative (but
sodium sulfate is contraindicated if formation of MetHb is
already noticeable).
Frequently, because of the danger to life, the
methemoglobinemia should already be treated on the site of
accident by applying a redox dye in addition to necessary
resuscitation and application of oxygen: toluidine blue (1 -
4 mg/kg bw, slowly i.v.; repeat this after 30 - 60 minutes
if necessary) or thionine (5 - 10 ml 0.2 % solution); as a
substitute methylene blue.
Apply ascorbic acid (about 1 g i.v., possibly later once
more i.m. or p.o.) as an adjuvant.
If the casualty suffers from G6PDH-deficiency, redox dyes
are ineffective.
Always hospitalize the casualty. Then, as a matter of
urgency following parameters: MetHb, functions of the heart/
circulatory system, CNS, kidneys, liver and hemogram.
Continuation of the MetHb treatment can become necessary for
several days. In serious cases, blood exchange transfusion
should be considered.
No ethanol whatsoever, not even following slight poisoning.

Recommendations :
Provide the physician information about the
substance/product and treatment already administered.
In workplaces in which exposure to dichloroanilines is
possible, polyethylene glycol (e.g. PEG 400) for skin
cleansing should always be available.
Note that redox dyes as MetHb antidotes can initially
increase the cyanotic skin color.
Persons who suffer from G6PDH deficiency and do not react
effectively to redox dyes must be treated by other measures
(blood exchange transfusion).
These persons should not work in any position where there is
a possibility of exposure to chloroanilines.

Fire-fighting measures

Classes of fires :
B Liquid or melting substances

Suitable extinguishing media :
Water (spray - not splash)
Extinguishing powder
Foam
Carbon dioxide

Instructions :
Seek immediate cover in case of sudden release and raising
of large quantities of dust.
Cool surrounding containers with water spray.
If possible, take container out of dangerous zone.
Shut off sources of ignition.
Stay on upwind side.
Do not allow runoff to get into the sewage system.

Special protective equipment :
Attention! Hazardous decomposition products may occur.
Nitrous gases (nitric oxides)
Hydrogen chloride
Wear self-contained breathing apparatus and special tightly
sealed suit.

Accidental release measures

Evacuate area. Warn affected surroundings.
The hazardous area may only be entered once suitable
protective measures are implemented. Only then can the
hazardous situation be removed.
Wear respiratory protection, eye protection, hand
protection and body protection (see chapter Personal
Protection).
Carefully sweep up, gather and remove. Avoid rising dust.
Afterwards ventilate area and wash spill site.

Endangerment of drinking water and environment:
Prevent escape into water, drainage, sewer, or the ground.
A hazard for drinking water sources when only small
quantities get into groundwater.
Inform the responsible authorities.
Maybe a hazard to the surrounding atmosphere if larger
quantities of the substance escape. Inform the authorities.

Handling and storage

TECHNICAL MEASURES - HANDLING
Workplace :
Provision of very good ventilation in the working area.
The floor should not have a floor drain.
Washing facility at the workplace required.
Eye bath required. These locations must be signposted
clearly.
When handling excessive amounts of the substance an
emergency shower is required.

Equipment :
Use only closed apparatus.
If release of the substance cannot be prevented, then it
should be suctioned off at the point of exit.
Consider emission limit values, a purification of waste
gases if necessary.
Label containers and pipelines clearly.

Advice on safer handling :
Take care to maintain clean working place.
The substance must not be present at workplaces in
quantities above that required for work to be progressed.
Do not leave container open.
Use leak-proof equipment with exhaust for refilling or
transfer.
Avoid spillage.
Fill only into labelled container.
Avoid any contact when handling the substance.
Avoid rising dust.
Use an appropriate exterior vessel when transporting in
fragile containers.

Cleaning and maintenance :
Use protective equipment while cleaning if necessary.
Avoid dust formation. Dust formation that cannot be avoided
must be collected regularly.
Use tested industrial vacuum cleaners or suction systems
for areas with a high risk of explosion.
Do not raise dust while cleaning.
Use of a blower for cleaning is not permitted.
Alternative: clean damp.


TECHNICAL MEASURES - STORAGE
Storage :
Keep in locked storage or only make accessible to
specialists or their authorised assistants.
Do not use any food containers - risk of mistake.
Containers have to be labelled clearly and permanently.
Store in the original container as much as possible.
Place fragile vessels in break-proof outer vessels.
Keep container tightly closed.
Store in a cool place.
Store in a dry place.
Keep container in a well-ventilated place.
Store small vessels in closable cupboards.
If more than 200 kg of toxic and highly toxic substances
are to be stored, or if the proportion of highly toxic
substances is more than 50 kg, then follow the rules of
TRGS 514.

Conditions of collocated storage :
Storage class 6.1 A (Combustible toxic substances)
Only substances of the same storage class should be stored
together.
Collocated storage with the following substances is
prohibited:
- Pharmaceuticals, foods, and animal feeds including
additives.
- Infectious, radioactive und explosive substances.
- Compressed, liquefied or pressure dissolved gases.
- Spontaneously flammable substances.
- Substances liberating flammable gases in contact with
water.
- Organic peroxides.
- Oxidizing substances of group 1, TRGS 515.
- Preparations containing ammonium nitrate, TRGS 511.
- Flammable solid substances of storage class 4.1 A.
- Combustible materials, e.g. paper, carton, wood, plastic
film.
Under certain conditions the collocated storage with the
following substances is permitted (For more details see the
Guideline of collocated storage of the VCI):
- Spray bottles.
- Oxidizing substances of group 2 and 3, TRGS 515.
- Combustible solids of storage class 11.
- Flammable solid substances of storage class 4.1 B.
The substance should not be stored with substances with
which hazardous chemical reactions are possible.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:
UN 3442 6.1/PG 2
Shipping information
Proper shipping name and description:
2,4 - Dichloraniline
Chemical name:
Benzenamine, 2,4-dichloro-(554-00-7)
Language:
English
SpecialProvisionsopen allclose all

Inland waterway transport (UN RTDG/ADN(R))

UN number:
UN 3442
Shippingopen allclose all
Remarksopen allclose all

Marine transport (UN RTDG/IMDG)

UN number:
UN 3442
Shipping information
Proper shipping name and description:
2,4 - Dichloraniline
Chemical name:
Benzenamine, 2,4-dichloro-(554-00-7)
Marine pollutant
Remarksopen allclose all

Air transport (UN RTDG/ICAO/IATA)

UN number:
UN 3442
Shipping information
Proper shipping name and description:
2,4-dichloroaniline (554-00-7)
Chemical name:
Benzenamine, 2,4-dichloro-(554-00-7)
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Body protection:
Depending on the risk, wear a tight, long apron and boots or suitable chemical protection clothing.
Wear flameproof protective clothing.
Wear dust tight protective clothing.


Respiratory protection:
In an emergency (e.g.: unintentional release of the substance) respiratory protection must be worn. Consider the maximum period for wear.
Respiratory protection: Gas filter A, Colour code brown.
For details on the requirements and the maximum concentrations for use, consult the "Regeln für den Einsatz von Atemschutzgeräten" (BGR 190).

Perhaps also necessary for improved protection:
Respiratory protection: Combination filter A - P2 or A - P3, recommended A - P3, colour code: brown-white.
For details on the requirements and the maximum concentrations for use, consult the "Regeln für den Einsatz von Atemschutzgeräten" (BGR 190).
Respiratory protection: insulating device.
Use for concentrations above the usage limits for filter devices, for oxygen concentrations below 17% volume, or in circumstances which are unclear.


Eye protection:
Sufficient eye protection should be worn.
Wear glasses with side protection.


Hand protection:
Use protective gloves. The glove material must be sufficiently impermeable and resistant to the substance.
Check the tightness before wear. Gloves should be well cleaned before being removed, then stored in a well ventilated location. Pay attention to skin care.
The following materials are suitable for protective gloves (Permeation time >= 8 hours):
Butyl rubber - Butyl (0,5 mm)
Fluoro carbon rubber - FKM (0,4 mm)

The times listed are suggested by measurements taken at
22 degree C and constant contact. Temperatures raised
by warmed substances, body heat, etc. and a weakening of
the effective layer thickness caused by expansion can lead
to a significantly shorter breakthrough time.
In case of doubt contact the gloves' manufacturer.
A 1.5-times increase / decrease in the layer thickness
doubles / halves the breakthrough time. This data only
applies to the pure substance. Transferred to mixtures of
substances, these figures should only be taken as an aid
to orientation.


Skin protection:
Skin protection preparations do not protect sufficiently against the substance. Wear protective gloves.
The skin must be washed with soap and water before breaks and at the end of work.
Apply fatty skin-care products after washing.


Industrial hygiene:
If at risk of contamination, foods, beverages and other articles of consumption must not be stored or consumed at the work areas. Special areas are to be designated for these purposes.
Avoid contact with skin. Do not allow the substance or its solution to dry on the skin. In case of contact wash skin.
Avoid contact with eyes. In case of contact rinse the affected eye(s).
Avoid inhalation of vapour/dust.
Avoid contact with clothing. Contaminated clothes must be exchanged and cleaned carefully.
Before a break it might be necessary to change clothes.
Provide washrooms with showers and if possible rooms with separate storage for street clothing and work clothing.

Stability and reactivity

Disposal considerations

Hazardous waste according to Waste Catalogue Ordinance
(AVV).
If there is no way of recycling it must be disposed of in
compliance with the respective national and local
regulations.

Collection of small amounts of substance:
Collect in container for toxic, flammable compounds.
Do not put/place waste into sink or dust bin.
Collection vessels must be clearly labelled with a
systematic description of their contents and with the
hazard symbol and the R and S phrases. Store the vessels in
a well-ventilated location. Entrust them to the appropriate
authorities for disposal.