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Description of key information

Groups of male F344/Slc rats received 110, 450, 1820 mg/kg bw/day of KCl in feed over a period of 2 years. The NOAEL was set 1820 mg/kg bw/day since nephritis was reported in all treatment groups as well as in the control group. With respect to the observed gastritis which is regarded to be a local effect a LOAEL(local) of 110 mg/kg bw/d was determined (Imai 1961, UNEP 2003).

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
1 820 mg/kg bw/day
Study duration:
chronic
Species:
rat

Additional information

ORAL APPLICATION

Groups of male F344/Slc rats received 110, 450, 1820 mg/kg bw/day of KCl in feed over a period of 2 years and were observed for clinical signs and mortality and were examined for gross and histopathological changes at the end of the treatment period (Imai 1961) The NOAEL was set 1820 mg/kg bw/day since nephritis was reported in all treatment groups as well as in the control group.

With respect to the observed gastritis which is regarded to be a local effect a LOAEL(local) of 110 mg/kg bw/d was determined (Imai 1961, UNEP 2003).

DERMAL APPLICATION

There is no data available on dermal repeated dose toxicity for potassium chloride.

APPLICATION VIA INHALATION ROUTE

There are no data availabel on repeated dose toxicity using the inhalation route for potassium chloride.

Justification for classification or non-classification

Based on the available data no classification/labelling is proposed

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