Registration Dossier
Registration Dossier
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EC number: 231-211-8 | CAS number: 7447-40-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: reported in brief
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku
- Author:
- Marhold JV
- Year:
- 1 972
- Bibliographic source:
- Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, 1972 ,p.8
- Reference Type:
- review article or handbook
- Title:
- Potasium chloride. toxicity profile
- Author:
- BIBRA
- Year:
- 1 989
- Bibliographic source:
- The British Industrial Biological Research|Association, Carshalton, UK
Materials and methods
- Principles of method if other than guideline:
- instillation of 500 mg KCl into the rabbit eye for 24 hours
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium chloride
- EC Number:
- 231-211-8
- EC Name:
- Potassium chloride
- Cas Number:
- 7447-40-7
- Molecular formula:
- KCl
- IUPAC Name:
- potassium chloride
- Details on test material:
- no further data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 3
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- other: Instillation of 500 mg KCl produced an irritant response in the rabbit eye at 24 hours
- Other effects:
- Instillation of 500 mgKCl produced an irritant response in the rabbit eye at 24 hours
Any other information on results incl. tables
Instillation of 500 mgKCl produced an irritant response in the rabbit eye at 24 hours
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Executive summary:
Instillation of 500 mg KCl produced an irritant response in the rabbit eye at 24 hours (Marhold 1972. BIBRA 1989)
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