Registration Dossier

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: data reported in brief

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku
Author:
Marhold JV
Year:
1972
Bibliographic source:
Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, 1972 ,p.8
Reference Type:
review article or handbook
Title:
Potasium chloride. toxicity profile
Author:
BIBRA
Year:
1989
Bibliographic source:
The British Industrial Biological Research|Association, Carshalton, UK

Materials and methods

Principles of method if other than guideline:
Single dermal application to the skin of rabbits
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium chloride
EC Number:
231-211-8
EC Name:
Potassium chloride
Cas Number:
7447-40-7
Molecular formula:
KCl
IUPAC Name:
potassium chloride
Details on test material:
no further data

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
no data
Observation period:
no data
Number of animals:
no data

Results and discussion

In vivo

Results
Irritation parameter:
other: overall irritation
Basis:
mean
Time point:
other: no data
Score:
ca. 0
Max. score:
6
Reversibility:
other: not adequate
Remarks on result:
other: the substance was evaluated to be not irritating to the skin of rabbits
Irritant / corrosive response data:
the substance was evaluated to be practically not irritating to the skin of rabbit
Other effects:
no data

Applicant's summary and conclusion

Executive summary:

Potassium chloride was applied to the skin of rabbit and was evaluated as practically not irritating to the skin ( grade 0/6Marhold 1972).

Categories Display