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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Distribution in body fluids and excretion of ingestes ammonium chloride, potassium chloride and sodiun chloride
Author:
Bourdillon J
Year:
1937
Bibliographic source:
Am J Physiol 120. 411-419

Materials and methods

Objective of study:
other: distribution and excretion
Principles of method if other than guideline:
single oral application to male volunteers and the changes in serum electrolytes, interstitial fluid volume and electrolyte excretion were obbserved for several hours.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium chloride
EC Number:
231-211-8
EC Name:
Potassium chloride
Cas Number:
7447-40-7
Molecular formula:
KCl
IUPAC Name:
potassium chloride
Details on test material:
no further details
Radiolabelling:
no

Test animals

Species:
human
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Duration and frequency of treatment / exposure:
single application
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
No. of animals per sex per dose / concentration:
number of volunteers in test is not mentioned
Control animals:
no

Results and discussion

Main ADME results
Type:
other: distribution and excretion
Results:
Cl anion diffuses into the interstitial fluid only, and does not enter the tissue cells; K kation diffuses in to the total body fluids; Serum HCO3 anion was reduced: one third excretion in urine and two third as KHCO3 into tissue cells

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion