Registration Dossier
Registration Dossier
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EC number: 231-211-8 | CAS number: 7447-40-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Distribution in body fluids and excretion of ingestes ammonium chloride, potassium chloride and sodiun chloride
- Author:
- Bourdillon J
- Year:
- 1 937
- Bibliographic source:
- Am J Physiol 120. 411-419
Materials and methods
- Objective of study:
- other: distribution and excretion
- Principles of method if other than guideline:
- single oral application to male volunteers and the changes in serum electrolytes, interstitial fluid volume and electrolyte excretion were obbserved for several hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium chloride
- EC Number:
- 231-211-8
- EC Name:
- Potassium chloride
- Cas Number:
- 7447-40-7
- Molecular formula:
- KCl
- IUPAC Name:
- potassium chloride
- Details on test material:
- no further details
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- single application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
- No. of animals per sex per dose / concentration:
- number of volunteers in test is not mentioned
- Control animals:
- no
Results and discussion
Main ADME results
- Type:
- other: distribution and excretion
- Results:
- Cl anion diffuses into the interstitial fluid only, and does not enter the tissue cells; K kation diffuses in to the total body fluids; Serum HCO3 anion was reduced: one third excretion in urine and two third as KHCO3 into tissue cells
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
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