Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Distribution in body fluids and excretion of ingestes ammonium chloride, potassium chloride and sodiun chloride
Author:
Bourdillon J
Year:
1937
Bibliographic source:
Am J Physiol 120. 411-419

Materials and methods

Objective of study:
other: distribution and excretion
Principles of method if other than guideline:
single oral application to male volunteers and the changes in serum electrolytes, interstitial fluid volume and electrolyte excretion were obbserved for several hours.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium chloride
EC Number:
231-211-8
EC Name:
Potassium chloride
Cas Number:
7447-40-7
Molecular formula:
KCl
IUPAC Name:
potassium chloride
Details on test material:
no further details
Radiolabelling:
no

Test animals

Species:
human
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Duration and frequency of treatment / exposure:
single application
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
No. of animals per sex per dose / concentration:
number of volunteers in test is not mentioned
Control animals:
no

Results and discussion

Main ADME results
Type:
other: distribution and excretion
Results:
Cl anion diffuses into the interstitial fluid only, and does not enter the tissue cells; K kation diffuses in to the total body fluids; Serum HCO3 anion was reduced: one third excretion in urine and two third as KHCO3 into tissue cells

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion