Registration Dossier
Registration Dossier
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EC number: 202-777-3 | CAS number: 99-66-1
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium valproate
- EC Number:
- 213-961-8
- EC Name:
- Sodium valproate
- Cas Number:
- 1069-66-5
- Molecular formula:
- C8H16O2.Na
- IUPAC Name:
- sodium 2-propylpentanoate
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 102.7 mg/L
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 10
- Sampling time:
- 6 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 59
- Sampling time:
- 16 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 68
- Sampling time:
- 28 d
- Details on results:
- The criterion for ready biodegradability under the conditions of a manometric respirometry test is the degradation of the test item of at least 60%, reached within a 10-day window. At the end of the 10-day window at day 16 the mean degradation of Sodium Valproate was 59% (ThODNH4) and therefore the 10 day window criterion was not passed. The mean biodegradation at test end after 28 days was 68% (ThODNH4).
The degradation rate of Sodium Valproate did not reach 60% within the 10 day window but after 28 days. Therefore, Sodium Valproate is considered biodegradable although failing the 10 day window.
BOD5 / COD results
- Results with reference substance:
- The reference item sodium benzoate was sufficiently degraded to 84% after 14 days and to 84% after 28 days of incubation, thus confirming the suitability of the aerobic activated sludge inoculum used.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The degradation rate of Sodium Valproate did not reach 60% within the 10-day window but after 28 days.
Therefore, Sodium Valproate is considered biodegradable although failing the 10 day window.
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