Registration Dossier
Registration Dossier
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EC number: 202-051-6 | CAS number: 91-22-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No reproduction study is available and it's not necessary to perform these development and / or fertility studies because quinoline is classified as carcinogen cat 2 and mutagen cat 3, so according to point R 7.6.6.3 of the Guidance of information requirements (Mai 2008), no reproduction toxicity studies are necessary because risk management measures are in place (see the CSR).
In addition, some information from in vitro studies show that quinoline has no estrogenic and no androgenic activity.
Furthermore, it has been shown in mutagenicity studies that the testis were not able to metabolize quinoline into its active derivative.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No data available.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
