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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to other aquatic organisms

Currently viewing:

Administrative data

Endpoint:
toxicity to other aquatic vertebrates
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
no data
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Neither EU nor OECD guideline is available for test on amphibian. It is impossible to evaluate the validity of this study.

Data source

Reference
Reference Type:
publication
Title:
Toxicity and Teratogenicety of Aromatic amines to Xenopus laevis
Author:
Dumont JN, Schultz TW, Jones RD
Year:
1979
Bibliographic source:
Bull Env contam toxicol 22: 159-166

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Exposure of Xenopus embryos to different concentrations of quinoline for 96 h
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Quinoline
EC Number:
202-051-6
EC Name:
Quinoline
Cas Number:
91-22-5
Molecular formula:
C9H7N
IUPAC Name:
quinoline
Details on test material:
no data

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Xenopus laevis

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
26.3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 22.1-31.3 mg/L

Any other information on results incl. tables

Table 1: Lethality and teratogenic effects of quinoline

Conc. mg/L

24 h

48 h

72 h

96 h

A/S

%

A/S

%

A/S

%

A/S

%

Dead + abnormal (%)

0

0/100

0

0/96

0

2/96

2

3/96

3

7

10

0/96

0

1/95

1

3/95

3

3/95

3

8

25

3/93

3

20/91

22

30/86

35

37/86

43

51

50

6/93

6

39/87

44

49/83

59

56/83

67

73

75

6/96

6

46/86

53

63/86

72

68/86

79

82

100

12/86

14

46/63

73

60/62

97

62/62

100

100

125

14/77

18

14/14

100

0/0

 

0/0

 

0

A/S = abnormal / survivors

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Remarks:
no validity criteria available
Conclusions:
The LC50 (96 h) on xenopus embryos is 26.3 mg/L.
Executive summary:

An acute toxicity test of quinoline on embryos of Xenopus laevis has been determined after exposure for 96 h to different concentrations.

The teratogenic effetcs were also recorded.

The LC50 (96h) is 26.3 mg/L.