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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study

Data source

Reference Type:
study report
Report date:

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
Epicutaneous patch test

Test material

Constituent 1
Chemical structure
Reference substance name:
Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides
EC Number:
EC Name:
Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides
Cas Number:
Molecular formula:
The substance is a quarternary ammonium chloride derived from fatty alcohol. The general chemical structure is R-N(Me)3+ Cl-, whereas the alkylrest R is variable for the main components C20 and C22 but also shorter and longer C-Chains (in smaller amounts)
N,N,N-trimethyl-C20-22-(even numbered)-alkyl-1-aminium chloride


Type of population:
Test type: Epicutaneous patch test with 1.0 % behentrimonium chloride in water
Subjects: Healthy male and female volunteers, age 17-80 years, nine of which with allergies, without visible skin lesions at the start of the study
Group size: 19 male and 31 female subjects
Route of exposure:
Reason of exposure:
Details on exposure:
1.0 % behentrimonium chloride in water
The test substance was applied to the skin of the back using usual test chambers. The test site was covered occlusively by adhesive plaster for 24 hours.
- Other: Skin reactions were evaluated 0 and 24 hours after removal of test patches.

Results and discussion

Results of examinations:
No signs of skin irritation were detected in any subject at 0 as well as at 24 hours after application.

Applicant's summary and conclusion

1.0 % behentrimonium chloride in water produced no skin irritation when applied under occlusion for 24 hours in a human epicutaneous patch test.