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EC number: 232-417-0 | CAS number: 8017-16-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- N/A to 1968-04-18
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study similar to OECD 423 with sufficient documentation on methods and results to evaluate data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Orthophosphoric acid
- EC Number:
- 231-633-2
- EC Name:
- Orthophosphoric acid
- Cas Number:
- 7664-38-2
- Molecular formula:
- H3O4P
- IUPAC Name:
- phosphoric acid
- Details on test material:
- - Name of test material (as cited in study report): thermal phosphoric acid
- Analytical purity: 75.4%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: SPF-Wister K
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 80-134 g
- Fasting period before study: 12 hrs
- Diet: After application rats received the standard-ALTROMIN R feed
- Water: tap water
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% aqueous solution
- Amount of vehicle (if gavage): 0.8 to 5.0- mL/100g-bw
- Doses:
- 0.8, 1.25, 2.0, 3.2, and 5.0 mL per 100 g body weight
- No. of animals per sex per dose:
- 10 female rats
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1.7 other: mL/100 g body weight
- Remarks on result:
- other: corresponding approximately to 2600 mg/kg
- Mortality:
- In the 0.8 mL/100 g-bw dose group there was no mortalities and in the 1.25 mL/100 g-bw group 2 of the 10 animals died. In the 2.00 mL/100 g-bw dose group 8 of the 10 animals died and in the 3.20 mL/100 g-bw and 5.0 mL/100 g-bw dose group all 10 of the animals died.
- Clinical signs:
- other: The animals died unbalanced, lying on tummy or flank, with breathing difficulties and cramps within 30 minutes to 24 hours after application.
- Gross pathology:
- The necropsy of the animals showed macroscopic strong chemical burns on the mucous membrane of the stomach.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for a 10% solution of 75.4% thermal phosphoric acid in rats was determined to be 1.70 ml/100 g body weight (approximately 2600 mg/kg bw).
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