Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient information to determine reliability

Data source

Reference
Reference Type:
publication
Title:
Urinary Excretion Of Choline Metabolites Following Choline Administration In Normals And Patients With Hepatobiliary Diseases
Author:
De la Huerga, J., and Popper., H.
Year:
1951
Bibliographic source:
J. Clin. Invest. 30(5): 463-470

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethylammonium chloride
EC Number:
209-810-0
EC Name:
Trimethylammonium chloride
Cas Number:
593-81-7
Molecular formula:
C3H9N.ClH
IUPAC Name:
trimethylazanium chloride

Results and discussion

Results:
Rapid elimination in the urine was observed in 2 patients with liver disease after an oral dose of 1.2-2.3 g TMA hydrochloride. No side-effects were observed.

Applicant's summary and conclusion