Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-810-0 | CAS number: 593-81-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- not specified
- Type:
- log Pow
- Partition coefficient:
- < -2.25
- Temp.:
- 25 °C
- Remarks on result:
- other: Trimethylamine part of the salt
- Type:
- log Pow
- Partition coefficient:
- < -3.4
- Temp.:
- 25 °C
- Remarks on result:
- other: Chloride part of the salt
- Details on results:
- No further details available.
- Conclusions:
- The study reports describes a reliable key information, without GLP compliance. The measurement is valid, since the procedure was equivalent / similar to OECD Guideline 107.
- Executive summary:
The partition coefficient was for the test substance was investigated according to a testing procedure which can be evaluated as equivalent or similar to the OECD Guideline 107 (BASF AG, 1988). The shake-flask method was used to determine the octanol-water coefficient (logPow) for the trimethylamine part as well as for the chlorine part of the salt. No pH adjustment was performed. Nitrogen and chloride were monitored individually in both phases and the surrounding temperature was 25 °C. For the trimethylamine part, the logPow was detected as < - 2.25 and for the chloride part of the salt the coefficient was determined as < -3.4.
Reference
The study was performed without adjustment of pH value.
Description of key information
Shake-flask method: logPow < -2.25 (Trimethylamine part); logPow < -3.4 (Chloride part)
QSAR prediction (logPow): -2.73
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.25
- at the temperature of:
- 25 °C
Additional information
The key value is given by an experimental result (Key study 1, 1988), equivalent to OECD Guideline 107.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
