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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: - very limited report in an review paper on the sensory irritation of different industrial chemicals

Data source

Reference
Reference Type:
publication
Title:
Further Studies on Sensory Response to Certain Industrial Solvent Vapors
Author:
Silverman L, Schulte, HF & First MW
Year:
1946
Bibliographic source:
Journal of Industrial Hygiene and Toxicology. 28 (6): 262-6

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
respiratory irritation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
12 volunteers were exposed to vapors of 1,2,3-trichloropropane of different concentrations for 15 min and acceptance levels were determined
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,3-trichloropropane
EC Number:
202-486-1
EC Name:
1,2,3-trichloropropane
Cas Number:
96-18-4
Molecular formula:
C3H5Cl3
IUPAC Name:
1,2,3-trichloropropane
Details on test material:
- Name of test material (as cited in study report): Trichloropropane
- specified as: CH2ClCHClCH2Cl (= 1,2,3-trichloropropane)
- specified by: boiling point (156.17 °C) and vapor pressure (8.5 mmHg at 40 °C)
- no further details given

Method

Type of population:
not specified
Subjects:
no data
Ethical approval:
not specified
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
- subjects were exposed at least to 50 and 100 ppm (= 300 and 600 mg/m³), probably also to higher concentrations that were not noted
Examinations:
no detailed description
Medical treatment:
not applicable

Results and discussion

Clinical signs:
- all subjects objected to concentrations of 100 ppm or higher during exposure for 15 min due to irritation of eyes and throat.
- at 50 ppm a borderline majority found this concentration acceptable for a 8 h shift

Applicant's summary and conclusion

Conclusions:
The respiratory sensory irritation threshold limits for 1,2,3-trichloropropane was tested in human volunteers during an exposure of 15 min to 50 and 100 ppm.
A borderline majority of the subjects found a concentration of 50 ppm (= 300 mg/m³) acceptable for an 8 h shift. All subjects objected to 100 ppm (= 600 mg/m³) due to irritation of eyes and throat.
Executive summary:

In the present study (Silverman 1946) the respiratory sensory irritation threshold limits for 1,2,3-trichloropropane was tested in human volunteers during an exposure of 15 min to 50 and 100 ppm.

A borderline majority of the subjects found a concentration of 50 ppm (= 300 mg/m³) acceptable for an 8 h shift. All subjects objected to 100 ppm (= 600 mg/m³) due to irritation of eyes and throat.