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EC number: 204-825-9 | CAS number: 127-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Irritant potency of the principal aliphatic chloride solvents on the skin and ocular mucous membranes of rabbits
- Author:
- Duprat P, Delsant L and Gradiski D
- Year:
- 1 976
- Bibliographic source:
- Eur J Toxicol. 3; 171-177
Materials and methods
- Principles of method if other than guideline:
- eye irritation study
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrachloroethylene
- EC Number:
- 204-825-9
- EC Name:
- Tetrachloroethylene
- Cas Number:
- 127-18-4
- Molecular formula:
- C2Cl4
- IUPAC Name:
- tetrachloroethene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ml undiluted tetrachloroethylene
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Remarks on result:
- other: A mild catarrhal conjunctivitis was observed. The total score for eye irritation was only 4 on a scale of 0‑110. This result does not trigger classification for eye irritation.
- Irritant / corrosive response data:
- A mild catarrhal conjunctivitis was observed. The total score for eye irritation was only 4 on a scale of 0‑110. This result does not trigger classification for eye irritation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- In the poorly reported data (assigned reliability “4”) on eye irritation potential of rabbits by Duprat et al. (1976), 0.1 ml of undiluted tetrachloroethylene was applied giving rise to a mild catarrhal conjunctivitis in rabbits. The total score for eye irritation was only 4 on a scale of 0‑110 but the scoring system is not detailed. The conclusion was made that this result does not trigger classification for eye irritation. However, in a study in human volunteers (Stewart et al., 1970), slight and transient eye irritation which developed within the first two hours of exposure and subsided before the end of the 7-hour exposure has been reported at about 100 ppm (690 mg/m3). In addition, according to the study with human volunteers performed by Rowe VK et al., 1952, the vapour concentration of tetrachloroethylene which will cause minimal irritation of the eyes in the unacclimated individual lies between 100 and 200 ppm, but 280 ppm causes a burning sensation in the eyes. Higher concentrations are provoking even more serious eye irritation effects. Therefore, a proposal was made by the evaluating MSCA to classify tetrachloroethylene as eye irritant category 2 based on GSH criteria.
- Executive summary:
In the poorly reported study (assigned reliability “4”) on the eye irritation potential of tetrachloroethylene in rabbits by Duprat et al. (1976), 0.1 ml of undiluted tetrachloroethylene was applied giving rise to a mild catarrhal conjunctivitis in rabbits. The total score for eye irritation was only 4 on a scale of 0‑110 but the scoring system is not detailed. The conclusion was made that this result does not trigger classification for eye irritation.
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