Registration Dossier

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit

Administration / exposure

Type of coverage:
occlusive
Duration of exposure:
24 hours
Doses:
1.3, 2.5, 5, 10 and 20 g/kg bw
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
Brief details are available of a study in which groups of 4 rabbits were exposed for 24 hours to undiluted tetrachloroethylene by dermal application under an occlusive dressing.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Mortality:
Mortality data (0/4 at 1.3 g/kg, ¼ at 2.5, 5 and 10 g/kg and 2/4 at 20 g/kg) indicate low toxicity, with the estimated LD50 being greater than 10 g/kg.
Clinical signs:
Convulsions occurred in 2-5 minutes at 20 g/kg.
Other findings:
There was necrosis at application sites at all doses.

Applicant's summary and conclusion