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EC number: 204-825-9 | CAS number: 127-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study, GLP status unknown, published in peer reviewed literature, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The subchronic toxicity of tetrachloroethylene (perchloroethylene) administered in the drinking water of rats
- Author:
- Hayes JR, Condie LW and Borzelleca JF
- Year:
- 1 986
- Bibliographic source:
- Fund Appl Toxicol. 7; 119-125
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrachloroethylene
- EC Number:
- 204-825-9
- EC Name:
- Tetrachloroethylene
- Cas Number:
- 127-18-4
- Molecular formula:
- C2Cl4
- IUPAC Name:
- tetrachloroethene
- Details on test material:
- - Name of test material (as cited in study report): Tetrachloroethylene- Analytical purity: 99+%- Lot/batch No.: 1019KJ
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Charles River breeding laboratories (Wilmington, Mass.)- Age at study initiation: 22-30 days of age- Weight at study initiation: males 165-208 g and females 120-175 g- Fasting period before study: 16 hour- Housing: computer randomized, caged individually, and quarantined for 1 week prior to initiation of the study. Maintained in stainless steel wire-bottomed suspended cages, color coded for dosage level- Diet: ad libitum- Water: ad libitum- Acclimation period: 1 weekENVIRONMENTAL CONDITIONS- Temperature (°C): 21-24- Humidity (%): 40-60- Air changes (per hr): no data- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: polyoxityethylated vegetable oil (Emulphor)
- Details on oral exposure:
- Exposure by gavage following an overnight fast (16 hours).The volume administered was 10 ml/kg bw.The doses were based upon initial range-finding studies (no more details reported).
- Doses:
- 2200-8850 mg/kg for males,2200-5500 mg/kg for females
- No. of animals per sex per dose:
- eight dosage groups, consisting of five rats per sex per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: hourly observations were made during the first 9 hr after administration of the substance followed by twice-daily observations for the next 14 days- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight, gross pathology
- Statistics:
- no data
Results and discussion
- Preliminary study:
- not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 835 mg/kg bw
- 95% CL:
- 3 318 - 4 437
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 005 mg/kg bw
- 95% CL:
- 2 689 - 3 358
- Mortality:
- All deaths occurred within the first 24 hr with a trend toward decreasing time to death with increasing dosage.
- Clinical signs:
- other: Tremors were observed at all doses. Tremors, ataxia, and central nervous system depression preceded death. Gross necropsy findings of the rats that died were essentially negative; hemorrhagic lungs and adrenals were observed in some animals.
- Gross pathology:
- No gross pathology was observed in the animals that survived the 14-day postadministration observation period.
- Other findings:
- Not reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
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