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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP, non-guideline study, acceptable for assessment
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990

Materials and methods

Principles of method if other than guideline:
Method to investigate the respiratory irritant potential of tetrachloroethylene in male rats.
GLP compliance:
yes
Type of method:
in vivo
Endpoint addressed:
respiratory irritation

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
limited information available

Test animals

Species:
rat
Sex:
male
Details on test animals and environmental conditions:
limited information available

Administration / exposure

Route of administration:
inhalation
Details on exposure:
limited information available
Details on analytical verification of doses or concentrations:
limited information available
Duration of treatment / exposure:
25 minutes
Frequency of treatment:
single exposure
Post exposure period:
not applicable
Doses / concentrations
Remarks:
Doses / Concentrations:10000 ppm (69000 mg/m3)Basis:
No. of animals per sex per dose:
no data
Details on study design:
not applicable

Examinations

Examinations:
limited information available
Positive control:
not applicable

Results and discussion

Details on results:
Exposures of about 10000 ppm (69000 mg/m3) for 25 minutes do not cause respiratory irritation.

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
Under the conditions of the study, exposures of about 10000 ppm (69000 mg/m3) for 25 minutes did not cause respiratory irritation.