Registration Dossier
Registration Dossier
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EC number: 225-768-6 | CAS number: 5064-31-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and accptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trisodium nitrilotriacetate
- EC Number:
- 225-768-6
- EC Name:
- Trisodium nitrilotriacetate
- Cas Number:
- 5064-31-3
- Molecular formula:
- C6H9NO6.3Na
- IUPAC Name:
- trisodium 2-[bis(carboxylatomethyl)amino]acetate
- Details on test material:
- - Name of test material (as cited in study report):CP56453, Monsanto Sample no. 173
- Physical state: solid
- Other: no detailed data provided
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Duration of exposure:
- 24 h
- Doses:
- 500, 1000, 2000 mg/kg bw. as a 10% aqueous solution
- No. of animals per sex per dose:
- 1/1
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The highest application of 2000 mg/kg bw was found to be non-lethal by skin absorption in male and female rabbits.
- Executive summary:
In an acute dermal toxicity study three male and female rabbits were dermally exposed to Na3NTA in water (10 % aqueous solution) for 24 hours at doses of 500, 1000, and 2000 mg/kg bw.
No mortality occurred – not even at highest concentration of 2000 mg/kg bw.
According to expert judgment trisodium nitrilotriacetate practically non-toxic by skin absorption. There were no symptoms of systemic toxicity observed. No weekness or loss of appetite. Since there was no death, no autopsies were performed.
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