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Short-term toxicity to fish

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Description of key information

 Based on the results of a fish test with TMAC, it is reasonably predicted that the 96-hr LC50of TMAOH in fish is higher than 100 mg/L (1.1 mM).

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An acute fish test was carried out with TMAC in a flow-through system according to a method similar to OECD203. No analytical measurements were performed. However, as the test was set up as flow-through, the test concentrations are kept stable. Furthermore, as the test substance is assumed to have a high water solubility, the actual test concentrations and nominal concentrations are deemed comparable. The 96h-LC50 of TMAC was determined to be 462 mg/L, based on nominal concentrations. In principle, the fish toxicity data of TMAC can be used to read across to TMAOH (see read-across document, attached in IUCLID section 13), resulting in a value of 359 mg/L using the molecular weight of TMAC/TMAOH = 109/91.However, considering that TMAOH has a strong alkaline property, the substance may exhibit toxicity to fish at much lower concentrations than TMAC. The alkalinity of TMAOH is almost the same as KOH and NaOH. In addition, it is well recognized that the effects of these latter compounds on fish is attributed to their pH effects. The minimal 96h-LC50 values of KOH and NaOH in fish have been reported to be 125 mg/L (3.1 mM) and 80 mg/L (1.4 mM), respectively (OECD/UNEP/WHO/ILO, 2004a, b). Based on these facts, it is reasonably predicted that the 96-hr LC50of TMAOH in fish is higher than 100 mg/L (1.1 mM).