Registration Dossier
Registration Dossier
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EC number: 200-843-6 | CAS number: 75-15-0
Endpoint summary
Administrative data
Description of key information
Cardiovascular Effects
There is inadequate evidence to support an association between repeated inhalation exposure to less than 10 ppm of CS2 and harm to cardiovascular health. Older occupational cohort studies, in which employees were exposed to concentrations of CS2 > 10 ppm, suggested cardiotoxicity at such levels. The utility of these findings is severely limited by methodological problems in the design and/or analysis of those older studies.
Ocular health
There is no evidence for an adverse ocular effect of occupational exposure to less than 10 ppm of CS2. While two studies suggest an effect at lower concentrations, lack of data on historical exposures of study participants limits their utility.
Neurotoxicity
Occupational inhalation exposure to less than 10 ppm of CS2 is associated with small magnitude, subclinical reductions in nerve conduction velocities and impaired psychomotor function. There is insufficient evidence to support an association between exposure to less than 10 ppm of CS2 and morphological CNS effects or subjective neurological complaints.
Reproductive toxicity
Based on the available studies it is concluded that repeated inhalation exposure to low levels (< 10 ppm) of CS2 in occupational settings does not present a risk to reproductive health. There is weak evidence suggesting that exposures above 10 ppm of CS2 are associated with decreased libido in men and increased prevalence of menstrual cycle disturbances in women.
Carcinogenicity
A limited number of studies have considered the carcinogenic potential of CS2. The available epidemiological evidence does not support an association between exposure to CS2 and risk of cancer.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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