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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Remarks:
QSAR prediction
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Internationally accepted QSAR method (Multicase). Prediction by Danish EPA (included in the OECD Toolbox Application).
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR prediction
Title:
Unnamed
Year:
1998

Materials and methods

Principles of method if other than guideline:
QSAR prediction by Danish EPA: Multicase model A33 (QPRF document is attached).

Multicase model A33: consists of chemicals reported to be able to induce acute dermatitis in humans and/or guinea pigs. The system includes more than 30 QSARs covering from 3 to 150 molecules with average r2 approximately of 0.8. The expert system yields a predictivity of 84% (Rosenkranz et al. 1999).

Test material

Constituent 1
Chemical structure
Reference substance name:
Camphene
EC Number:
201-234-8
EC Name:
Camphene
Cas Number:
79-92-5
Molecular formula:
C10H16
IUPAC Name:
1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

Results and discussion

Any other information on results incl. tables

The conclusion of the QSAR prediction is that the substance Camphene is not sensitising.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
The conclusion of the QSAR prediction is that the substance Camphene is not sensitising.
Executive summary:

QSAR prediction by Danish EPA: Multicase model A33.

Multicase model A33: consists of chemicals reported to be able to induce acute dermatitis in humans and/or guinea pigs. The system includes more than 30 QSARs covering from 3 to 150 molecules with average r2 approximately of 0.8. The expert system yields a predictivity of 84% (Rosenkranz et al. 1999).

The conclusion of the QSAR prediction is that the substance Camphene is not sensitising.