Registration Dossier
Registration Dossier
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EC number: 201-234-8 | CAS number: 79-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Test method is not according to any guideline. No GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- The permeability of human skin to terpenes was studied by Römmelt et al., who demonstrated percutaneous absorption from 30 -min full baths (Kneipp) containing pine oil additives by measuring camphene and other terpene components in the expired air of one human subject. The results of dermal absorption were calculated with respect to the values obtained from the elimination of camphene through the lungs after IV administration.
- GLP compliance:
- no
Test material
- Reference substance name:
- Camphene
- EC Number:
- 201-234-8
- EC Name:
- Camphene
- Cas Number:
- 79-92-5
- Molecular formula:
- C10H16
- IUPAC Name:
- 2,2-dimethyl-3-methylidenebicyclo[2.2.1]heptane
- Details on test material:
- - Name of test material (as cited in study report): Camphene
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Strain:
- other: not applicable
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- In all experiments, the water and the bath temperature were kept constant.
The subject breathed through a breathing mask with double valve.
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- water
- Duration of exposure:
- 30 minutes
- Doses:
- 150 mL pine bath oil in 450 L water
The exact dose was controlled by a pressure reducer in the stock tank and a diving bell spirometer, which functioned as a variable reservoir. - No. of animals per group:
- One human subject (no data on sex)
- Control animals:
- no
- Details on study design:
- Observation period: 24 hours
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- no effects
- Total recovery:
- A human subject immersed in a bath containing pine needle oil, exhaled terpenes, including 0.67 µL camphene, within 5 hr.
A constant of 81 µL/cm2/hr was calculated for the percutaneous absorption of camphene from the bath.
The total quantity of Kneipp pine oil extract absorbed through the skin of an adult person from a 30-min full bath containing 150 mL pine bath oil in 450 L water bath water was estimated to be 0.04 mg, which must be considered to be within a range capable of producing therapeutic effects.
Any other information on results incl. tables
The test subject exhaled terpenes, including 0.67 µL camphene, within 5 hr. A constant of 81 µL/cm2/hr was calculated for the percutaneous absorption of camphene from the bath.
Applicant's summary and conclusion
- Conclusions:
- The test subject exhaled terpenes, including 0.67 µL camphene, within 5 hr. A constant of 81 µL/cm2/hr was calculated for the percutaneous absorption of camphene from the bath.
- Executive summary:
The permeability of human skin to terpenes was studied by Römmelt et al., who demonstrated percutaneous absorption from 30 -min full baths (Kneipp) containing pine oil additives by measuring camphene and other terpene components in the expired air of one human subject. The results of dermal absorption were calculated with respect to the values obtained from the elimination of camphene through the lungs after IV administration.
The test subject exhaled terpenes, including 0.67 µL camphene, within 5 hr. A constant of 81 µL/cm2/hr was calculated for the percutaneous absorption of camphene from the bath.
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