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EC number: 607-759-2 | CAS number: 25618-55-7
All treated animals survived the scheduled study period.
No clinical signs were observed in any animals of the control group or group 2 (25%). About 3 hours after the first topical application, a slight ear erythema was observed at both dosing sites in all mice of group 4 (100%, undiluted), persisting for a total of four days. On the second application day, a slight ear erythema was observed at both dosing sites in all mice of group 3 (50%), persisting for a total of two days.
In this study Stimulation Indices (S.I.) of 1.4, 2.1, and 1.9 were determined with the test item at concentrations of 25, 50, and 100 % in ethanol/water (7:3, v:v), respectively.
In this study the test item dissolved in ethanol/water (7:3, v:v) was assessed for its possible contact allergenic potential.
For this purpose a local lymph node assay was performed using test item concentrations of 25, 50 and 100 % by topical application to the dorsum of each ear lobe (left and right) for three consecutive days. A control group of four mice was treated with the vehicle only. Five days after first topical application the mice were injected intravenously into a tail vein with radio-labelled thymidine. Approximately five hours after intravenous injection, the mice were sacrificed, the draining auricular lymph nodes excised and pooled per group. Single cell suspensions of lymph node cells were prepared from pooled lymph nodes which were subsequently washed and incubated with trichloroacetic acid overnight.The proliferative capacity of pooled lymph node cells was determined by the incorporation of radio-labelled thymidine measured in a scintillation counter.
The test item was not a skin sensitiser in this assay.
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