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Short-term toxicity to aquatic invertebrates

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Description of key information

EC50 (48) > 1000 mg/L (nominal) for Daphnia magna (OECD 202, limit test)

Key value for chemical safety assessment

Additional information

Since no studies investigating the toxicity of 1,2,3-Propanetriol, homopolymer (CAS 25618-55-7) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the two structurally related analogue substances Reaction mass of 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol,3-(2,3-dihydroxypropoxy) propane-1,2-diol,3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol (List No. 915-741-3) and glycerol (CAS 56-81-5) was conducted. This read-across is justified in detail in the overall endpoint summary in IUCLID Section 6.1. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substances were used for the assessment. Both read-across substances represent main components of the target substance (mono- to tetraglycerol). Thus, the aquatic toxicity pattern given by these read across substances are considered to be adequately assessing the aquatic toxicity pattern of 1,2,3-Propanetriol, homopolymer (CAS 25618-55-7).

The key study investigated the toxicity of reaction mass of 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol, 3-(2,3-dihydroxypropoxy)propane-1,2-diol,3- [3-[3-(2,3-dihydroxypropoxy)- 2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol (List No. 915-741-3) to aquatic invertebrates (Jansen 1992). The test was performed according to the OECD Guideline 202 under GLP conditions using Daphnia magna as test organism. A limit test with a test substance concentration of 1000 mg/L was applied under static conditions. The test substance concentration was analytically confirmed. As no immobilized daphnia were recorded after an exposure time of 48 h the EC50 value is determined to be >= 1000 mg/L based on the nominal concentration.

A supporting study was performed with the read-across substance glycerol (CAS 56-81-5). The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of the study results (Bringmann & Kühn, 1977). Daphnia magna was exposed to the test substance over an exposure time of 24 h, which indicate that this study is insufficient to cover the endpoint; however, the result is considered to be reliable and thus the test result can be used as supporting information. The EC50 value is determined to be >= 10000 mg/L based on the nominal concentration.

Based on the results from the read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which show consistent results for the main components of the target substance (mono-, polyglycerols), it can be concluded that 1,2,3-Propanetriol, homopolymer (CAS 25618-55-7) will not exhibit acute effects to aquatic invertebrates up to 100 mg/L. Thus, it can be considered that the substance is not harmful to aquatic invertebrates.