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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Section 173.240 under Title 49 of the code of Federal Regulations (Federal Register, 1973).
Deviations:
not specified
GLP compliance:
no
Remarks:
Study pre-dates GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Potassium tetraborate powder.
- Physical state: White powder with a slight odour.

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
abraded
Vehicle:
not specified
Controls:
no
Amount / concentration applied:
No data
Duration of treatment / exposure:
4 h
Observation period:
48 h
Number of animals:
Six
Details on study design:
TEST SITE
- Area of exposure: 1 inch by 1 inch on the saddle.
- % coverage:
- Type of wrap if used: 12-ply surgical gauze held in place with adhesive tape. After application of the patches, the trunk of each rabbit was wrapped with rubber dental damming secured with staples.

REMOVAL OF TEST SUBSTANCE
- Washing: Gently sponged with a moistened towel.
- Time after start of exposure: 4 h

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 h
Score:
0
Max. score:
8
Reversibility:
other: Not applicable
Remarks on result:
other: Result on intact skin.
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 h
Score:
0
Max. score:
8
Reversibility:
other: Not applicable
Remarks on result:
other: Result on abraded skin.
Irritant / corrosive response data:
Very slight erytehma was noted. No corrosive effects were noted at any time.

Any other information on results incl. tables

Primary irritation and corrosive scores in rabbits following a 4-h patch application of potassium tetraborate powder:

Rabbit

No.

Skin

Erythema-Eschar Observation

Edema Observation

4 h

24 h

48 h

4 h

24 h

48 h

55

Intact

0

0

0

0

0

0

Abraded

0

0

0

0

0

0

56

Intact

0

0

0

0

0

0

Abraded

0

0

0

0

0

0

57

Intact

0

0

0

0

0

0

Abraded

1

1

0

0

0

0

58

Intact

0

0

0

0

0

0

Abraded

0

0

0

0

0

0

59

Intact

0

0

0

0

0

0

Abraded

0

0

0

0

0

0

60

Intact

0

0

0

0

0

0

Abraded

1

0

0

0

0

0

Applicant's summary and conclusion

Interpretation of results:
other: Not corrosive
Remarks:
Criteria used for interpretation of results: other: Section 173.40 under Title 49 of the Code of Federal Regulations (Federal Register, 1973).
Conclusions:
The corrosive potential of potassium tetraborate was assessed and found not corrosive according to Section 173.40 under Title 49 of the Code of Federal Regulations (Federal Register, 1973).