Registration Dossier
Registration Dossier
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EC number: 246-356-2 | CAS number: 24613-89-6
Carcinogenicity
Administrative data
Description of key information
There are a multitude of published studies, including both animal and epidemiological studies, that address the carcinogenicity of Cr(VI) substances. The literature is summarised in various peer reviewed publications, e. g., EU RAR 2005 and ATSDR, 2012.
Chromium(VI) causes lung tumours in humans and animals by the inhalation route and tumours of the gastrointestinal tract in animals by the oral route. These are both local, site-of-contact tumours – there is no evidence that Cr(VI) causes tumours elsewhere in the bo
Reference dose response relationships for the carcinogenicity of hexavalent chromium substances are documented in the ECHA publication "Application for authorisation: Establishing a reference dose response relationship for carcinogenicity of hexavalent chromium", Ref RAC/27/2013/06 Rev.1, dated 4 Dec 2013.
Key value for chemical safety assessment
Justification for classification or non-classification
Dichromium tris(chromate) is classified as a Carcinogen Category 1B, H350 according to Regulation (EC) No 1272/2008. No studies are available for dichromium tris(chromate), however studies in rats and mice with another Cr (VI) salt (sodium dichromate) demonstrated clear evidence of carcinogenicity via the oral exposure route. Therefore, no change to the current classification is proposed.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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