Registration Dossier
Registration Dossier
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EC number: 246-356-2 | CAS number: 24613-89-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The EU RAR reports the results of a number of studies of various designs achieving comparable results.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- European Union Risk Assessment Report: chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate and potassium dichromate
- Author:
- European Chemicals Bureau
- Year:
- 2 005
- Bibliographic source:
- 3rd. Priority List; Volume 53
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The review summarises the results of a number of studies of skin irritation performed in different species and using various, largely non-standard methods.
- GLP compliance:
- no
- Remarks:
- published studies, predating GLP
Test material
- Reference substance name:
- Sodium dichromate
- EC Number:
- 234-190-3
- EC Name:
- Sodium dichromate
- Cas Number:
- 10588-01-9
- Molecular formula:
- Cr2H2O7.2Na
- IUPAC Name:
- sodium dichromate
- Reference substance name:
- Sodium chromate
- EC Number:
- 231-889-5
- EC Name:
- Sodium chromate
- Cas Number:
- 7775-11-3
- Molecular formula:
- CrH2O4.2Na
- IUPAC Name:
- disodium dioxido(dioxo)chromium
- Reference substance name:
- Potassium dichromate
- EC Number:
- 231-906-6
- EC Name:
- Potassium dichromate
- Cas Number:
- 7778-50-9
- Molecular formula:
- Cr2H2O7.2K
- IUPAC Name:
- potassium dichromate
- Reference substance name:
- chromium (VI) trioxide
- IUPAC Name:
- chromium (VI) trioxide
- Details on test material:
- Studies were performed using sodium chromate, sodium dichromate, potassium dichromate, and chromium trioxide.
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- other: various
- Strain:
- other: various
Test system
- Type of coverage:
- other: various
- Preparation of test site:
- other: various
- Vehicle:
- other: undiluted or saline
- Controls:
- not specified
- Duration of treatment / exposure:
- The review summarises the results of a number of studies of skin irritation performed in different species and using various non-standard methods
- Observation period:
- Various
- Number of animals:
- Various
Results and discussion
Any other information on results incl. tables
All of the water-soluble Cr (VI) compounds were found to be skin irritants in the studies sumamrised in this review. Chromium (VI) trioxide is considered to be corrosive as a consequence of its low pH.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The findings of a number of non-standard studies in various animal species indicate that water-soluble Cr (VI) compounds sodium chromate, sodium dichromate and potassium dichromate are likely to be skin irritants.
- Executive summary:
The EU RAR summarises the results of a number of non-standard studies in animals which indicate that the water-soluble Cr (VI) compounds sodium chromate, sodium dichromate and potassium dichromate are likely to be skin irritants. Experience from occupational exposure to these compounds indicates severe dermal irritation / corrosivity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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