Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-288-1 | CAS number: 520-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Hesperidin has shown in a test according to OECD 301B to be readily biodegradable. As degradation in the toxicity flask was 72% after 14 days, the test item can be stated as “not toxic towards the inoculum in a concentration of 37.6 mg/L”.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Hesperidin has shown in a test according to OECD 301B to be readily biodegradable. Degradation behaviour of positive control and toxicity control was acceptable. Abiotic degradation was not observed. Both replicates of the test item showed very good correspondence. If degradation in the toxicity flask is below 25% after 14 days, the test item can be considered as toxic towards the inoculum. As degradation in the toxicity flask was 72% after 14 days, the test item can be stated as “not toxic towards the inoculum in a concentration of 37.6 mg/L”. Ready degradability is defined in the guidelines as degradation surpassing 60% within 10 days after reaching a level of 10%. Therefore, the test item Hesperidin can be considered as “readily biodegradable”, as 75 % degradation were reached at the end of the 10-day-window.. No observations were made which might cause doubts concerning the validity of the study outcome. The result of the test can be considered valid.
Furtheron an OECD 301B test was performed on Flavonoides 90% Micro (consisting of 90% diosmin and 10% hesperidin) which also showed ready biodegradability, reaching 73% degradation following the 1 -day window and 100% after 28 days. Diosmin is structurally very similar to hesperidin and is obtained by oxidation of the central flavonoide ring, thus having just 2 hydrogen atoms less than hesperidin. Hence, these results do confirm the similarity of diosmin and hesperidin, both being flavonoides sharing the same carbohydrate moiety and support the ready biodegradability of this group of chemicals.
In accordance with column 1 of REACH (REGULATION (EC) No 1907/2006) Annex IX, further studies on surface water simulation testing do not need to be conducted as the substance hesperidin is readily biodegradable (80% biodegradation within 28 days).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.