4-methyl-m-phenylene diisocyanate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Method: Draize Test

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

m-tolylidene diisocyanate

EC Number:

247-722-4

EC Name:

m-tolylidene diisocyanate

Cas Number:

26471-62-5

Molecular formula:

C9 H6 N2 O2

IUPAC Name:

m-tolylidene diisocyanate

Details on test material:

Data on physical and chemical properties, eco-toxicity and toxicity can be used for read-across from 2,4-TDI to 2,6-TDI and mixed
TDI isomers (i.e. 80/20, 65/35, 2,4/2,6 ratios). 2,4 TDI is the major component of the TDI mixed isomers and so has the major influence
on their properties and effects. The reactivity of the 2,6-TDI isomer is somewhat less than that of 2,4-TDI but is of the same order of
magnitude. It may therefore be concluded that the effects of 2,6-TDI will be similar to those of 2,4-TDI. This is in fact observed where
there are overlapping data.

Test animals / tissue source

Species:

rabbit

Test system

Controls:

yes, concurrent no treatment

Amount / concentration applied:

undiluted
Amount applied: 0.1 ml

Observation period (in vivo):

14 days

Number of animals or in vitro replicates:

6

Details on study design:

Comment: not rinsed

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 1, 24, 72h, 7d, 14d

Score:

36.5

Max. score:

110

Reversibility:

fully reversible within: 14d

Remarks on result:

other: Maximum score at 24h, see table in free text for details

Any other information on results incl. tables

animal #	Total score (cornea + iris + conjunctiva)
.	1 min	1 hr	24 hrs	72 hrs	7 days	14 days
1	0	18	18	10	8	0
2	2	18	41	18	8	6
3	2	18	41	61	66	61
4	2	12	33	17	8	6
5	2	18	43	36	10	0
6	2	16	43	41	41	20
Averages	2	16.7	36.5	30.5	23.5	15.4

Irritation Index = 36.5/110.0

Highlly irritating. All effects resolved by day 14.

Applicant's summary and conclusion

Interpretation of results:

highly irritating

Remarks:

Migrated information

Conclusions:

Classification: irritating