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EC number: 260-350-7 | CAS number: 56706-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-09-24 to 1998-09-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Guideline study with acceptable restrictions. The study was conducted according to an appropriate OECD test guideline. It was not compliant with GLP. The restriction was that there was no analysis of exposure concentrations and it is likely that the solubility of the test substance was exceeded in the test.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- no
- Details on sampling:
- not applicable
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 10 mg and 1 mg of the test substance were weighed onto a small polyethylene platelett. The plateletts were then transferred to 1 litre polyethylene bottles. The bottles were each filled with 1 litre of oxygen-saturated dilution water and sealed with a screw cap. They were then shaken for 20 hours at 20+/-1.5ºC before being allowed to settle for 4 hours. The resulting solutions were then transferred into four replicate 100 ml polyethylene test vessels. The vessels were sealed during the exposure period.
- Controls: Dilution water
- Evidence of undissolved material (e.g. precipitate, surface film, etc): the solubility of the test substance is noted as being in the order of 1 mg/l and therefore it is possible that undissolved test material was present at the highest loading rate. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: Dr. Knie, LWA
- Age at study initiation (mean and range, SD): <24 hours
- Method of breeding: laboratory stock culture
- Feeding during test: none
ACCLIMATION
- Acclimation conditions: same as test
- Type and amount of food: green algae Scenedesmus subspicatus
- Feeding frequency: daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- no data
- Test temperature:
- 21.0-21.4ºC
- pH:
- 7.20-7.43
- Dissolved oxygen:
- 7.5-8.0 mg/l
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal loading rates: 1 and 10 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: flasks
- Type: closed
- Material, size, headspace, fill volume: polyethylene, 100 ml, no headspace, 100 ml
- Aeration: none
- Other: The test vessels were placed on a light table to discourage the test organisms from coming into contact with undissolved test substance on the surface of the test medium.
- Renewal rate of test solution (frequency/flow rate): static test
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 1 dahnid/20 ml test medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: drinking water
- Culture medium different from test medium: no
- Intervals of water quality measurement: start and end of test
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light, 8 h dark
EFFECT PARAMETERS MEASURED: mobility after 24 and 48 hours
TEST CONCENTRATIONS
- Spacing factor for test loading rates: 10
- Justification for using less concentrations than requested by guideline: no data
- Range finding study: no data - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- < 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- < 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- < 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: expected water solubility of the test substance
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- < 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: expected water solubility of the test substance
- Basis for effect:
- mobility
- Details on results:
- - Other biological observations: Microscopic examination of the test organisms exposed to both treatments showed evidence of physical fouling of the antennae with the test substance. The report authors attribute the observed immobility of the test organisms to this phenomenon.
- Mortality of control: 0
- Effect concentrations exceeding solubility of substance in test medium: The report authors note the presence of undissolved test material causing fouling of the test organisms. - Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- No statistical test were applied to the results
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-h EL50 value of <1 mg/l and NOELR of <1 mg/l) have been determined for the effects of the test substance on mobility of Daphnia magna. It is likely that the observed effects on the test organisms resulted, at least in part, from exposure to undissolved test material even though steps were taken to avoid this in the test procedure.
Reference
Table 1. Test results
Nominal test substance loading rate (mg/l) | Mean percentage immobilisation after 24 hours | Mean percentage immobilisation after 48 hours |
0 (Control) | 0 | 0 |
1 | 75 | 75 |
10 | 95 | 100 |
Description of key information
EL50 (48 h): <1 mg/l (nominal) based on: mobility of Daphnia magna (nominal) (OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Evidence of physical fouling was seen in the test at both loading levels and therefore effects seen are attributed to physical effects caused by undissolved test substance or precipitated by-products. Therefore, this value is not used as the basis of PNECaquatic values.
Key value for chemical safety assessment
Additional information
A 48-hour EL50 value of <1 mg/l has been determined for effects of 4,4,13,13-tetraethoxy-3,14 -dioxa-8,9-diatha-4,13-disilahexadecane (S2) (CAS 56706-10-6, EC 260-350-7) on the mobility of Daphnia magna in a test conducted according to OECD TG 202 (Evonik Degussa, 1998b). In this study, the water solubility of the substance (0.014 mg/l at 20°C) was exceeded at the tested loading rates and undissolved test substance was observed to be present in the test media. It is likely that, because of the test medium preparation method and exposure regime, the test organisms were exposed to a mixture of the parent substance, the hydrolysis products and undissolved test substance and/or precipitated oligomeric by-products. It is likely that the observed effects on the test organisms resulted, at least in part, from exposure to undissolved test material or precipitate, even though steps were taken to avoid this in the test procedure. The results of this test were selected as key in preference to those of a second test of equal reliability, because they gave a more conservative 48 h EL50.
A 48-hour EL50 value of >10 mg/l has been determined for the effects of the read-across substance, bis[3-(triethoxysilyl)propyl]polysulfides (CAS 211519-85-6, EC 915-673-4), on the mobility of Daphnia magna. The water solubility of the substance (0.01-0.014 mg/l, estimated) was exceeded at the tested loading rates and undissolved test substance was observed to be present in the test media. It is likely that, because of the prolonged test medium preparation phase, the test organisms were exposed to a mixture of the parent constituents and a mixture of the monomeric silanol hydrolysis product and its siloxane oligomers. Insoluble oligomers may have precipitated out of solution to an extent during the media preparation and during the test. The test results have been interpreted in this context. This is reflected in the observation of turbidity in test media, although no analytical verification was performed. The test substance is a multiconstituent reaction mass of 4,4,15,15-tetraethoxy-3,16-dioxa-8,9,10,11-tetrathia-4,15-disilaoctadecane and 4,4,14,14-tetraethoxy-3,15-dioxa-8,9,10-trithia-4,14-disilaheptadecane and 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane. One constituent is the registered substance (CAS 56706-10-6).
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