Registration Dossier
Registration Dossier
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EC number: 201-196-2 | CAS number: 79-33-4
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Medium:
- methanol
- Solubility:
- 78.6 other: % w/w
- Temp.:
- 20 °C
- Medium:
- ethanol
- Solubility:
- 70.9 other: % w/w
- Temp.:
- 20 °C
- Medium:
- other: n-propanol
- Solubility:
- 62.4 other: % w/w
- Temp.:
- 20 °C
- Medium:
- isopropanol
- Solubility:
- 63.4 other: % w/w
- Temp.:
- 20 °C
- Medium:
- n-butanol
- Solubility:
- 54.5 other: % w/w
- Temp.:
- 20 °C
- Medium:
- other: 2-ethylhexanol
- Solubility:
- 29 other: % w/w
- Temp.:
- 20 °C
- Medium:
- other: hexane
- Solubility:
- 0.005 other: % w/w
- Temp.:
- 20 °C
- Medium:
- toluene
- Solubility:
- 0.11 other: % w/w
- Temp.:
- 20 °C
- Medium:
- diethyl ether
- Solubility:
- 38.7 other: % w/w
- Temp.:
- 20 °C
- Medium:
- other: tetrahydrofuran
- Solubility:
- 65.1 other: % w/w
- Temp.:
- 20 °C
- Test substance stable:
- yes
- Conclusions:
- Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.
- Executive summary:
The objective of this piece of research was to determine the solubility of lactic acid (crystals) in a number of common organic solvents and Purac products. With the results the best solvent(s) could be chosen to wash lactic acid crystals. Another objective was to increase the basic knowledge on lactic acid. Results were obtained by stirring dry lactic acid crystals at a certain temperature in a solvent. After 0.75 - 1 hour a sample was taken and analyzed for lactic acid (free acidity). The results are for pure monomeric lactic acid, therefore the solubility for lactic acid containing oligomers and/or water can be different.
Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reference
Description of key information
Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
