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Additional information

Reactive Blue 19 was tested for mutagenicity with the bacterial strains TA100, TA1535, TA1537, TA1538, TA98 of Salmonella typhimurium and Escherichia coli WP2uvrA and in an HPRT assay in mammalian cells (V79). The test substance is not mutagenic in these test systems either with or without exogenous metabolic activation at the dose levels investigated.

Reactive Blue 19 was tested for clastogenicity and aneugenicity in the in vitro chromosome aberration assay (V79 cells) and the in vivo micronucleus test in the mouse. The results indicated that, under the conditions of the present studies, the test substance is not genotoxic in these test systems.

Short description of key information:
In vitro studies negative and in vivo studies negative.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification