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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Principles of method if other than guideline:
Method: other (measured): Monsanto Environmental Sciences method ES-79-M-15: Log Kow of the substance was measured by equilibrating aqueous solutions of radiolabelled compounds with n-octanol. The concentrations of the substance in each phase were determined by Liquid Scintillation Counting (LSC).
GLP compliance:
no
Type of method:
other: equilibrating aqueous solutions of radiolabelled compounds with n-octanol
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
-3.4
Remarks on result:
other: Temperature and pH not stated

Test concentration 
Kow 50 mg/l      4.46 x 10-4
500 mg/l         3.49 x 10-4


Test concentrations are expressed as active acid.

Conclusions:
Kow values of 4.46E-4 and 3.49E-4 were was determined at 100 ppm and 1000 ppm respectively in a reliable study conducted according to generally accepted scientific principles.

Description of key information

Partition coefficient: log Kow -3.4

Key value for chemical safety assessment

Log Kow (Log Pow):
-3.4

Additional information

A log Kow value of -3.4 was determined for DTPMP-H in a reliable study conducted according to a generally accepted scientific principles. The result is considered to be reliable and has been assigned as key study.

Another log Kow value of -8.2 was reported for DTPMP-H using atom fragment contribution method. The fragment coefficients are supported by a collection of reliable data. Therefore, the calculated result is considered to be suitable for supporting study.