[[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Principles of method if other than guideline:

Method: other (measured): Monsanto Environmental Sciences method ES-79-M-15: Log Kow of the substance was measured by equilibrating aqueous solutions of radiolabelled compounds with n-octanol. The concentrations of the substance in each phase were determined by Liquid Scintillation Counting (LSC).

GLP compliance:

no

Type of method:

other: equilibrating aqueous solutions of radiolabelled compounds with n-octanol

Partition coefficient type:

octanol-water

Key result

Type:

log Pow

Partition coefficient:

-3.4

Remarks on result:

other: Temperature and pH not stated

Test concentration 
K_ow 50 mg/l      4.46 x 10^-4
500 mg/l         3.49 x 10^-4

Test concentrations are expressed as active acid.

Conclusions:

Kow values of 4.46E-4 and 3.49E-4 were was determined at 100 ppm and 1000 ppm respectively in a reliable study conducted according to generally accepted scientific principles.

Description of key information

Partition coefficient: log K_ow -3.4

Key value for chemical safety assessment

Log Kow (Log Pow):

-3.4

Additional information

A log K_ow value of -3.4 was determined for DTPMP-H in a reliable study conducted according to a generally accepted scientific principles. The result is considered to be reliable and has been assigned as key study.

Another log K_ow value of -8.2 was reported for DTPMP-H using atom fragment contribution method. The fragment coefficients are supported by a collection of reliable data. Therefore, the calculated result is considered to be suitable for supporting study.