Registration Dossier
Registration Dossier
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EC number: 270-736-7 | CAS number: 68477-53-2 A complex combination of organic compounds obtained by the distillation of products from a steam cracking process. It consists of unsaturated hydrocarbons having carbon numbers predominantly in the range of C5 through C12.
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Non human information
In the key study, sensitisation potential of dicyclopentadiene 75% was investigated in female guinea pigs in a modified (9 -induction) Buehler test, according to OECD guideline 406. Guinea pigs were dermally exposed to 0.5 mL undiluted dicyclopentadiene 75% for each of 9 induction phases (Safepharm, 1989e). Scattered mild redness was commonly seen at the induction sites during the induction phase. Other adverse skin reactions were fissuring, dry, thickened, straw-coloured skin (possible hyperkeratinisation), loss of skin suppleness, superficial cracking of the skin and small superficial scattered scabs. These reactions sometimes precluded evaluation of erythema. Following challenge with 0.2 mL undiluted dicyclopentadiene 75%, no skin responses were noted in test or control animals at 24 or 48 hours after challenge. Dicyclopentadiene 75% was therefore considered to be a non-sensitiser to guinea pig skin.
In the supporting study (Litton Bionetics, 1976a), 8 guinea pigs were induced with 10 intracutaneous injections (3/week) of 0.1% dicyclopentadiene (0.05 – 0.1mL). No skin reactions were observed. Two weeks after the last dose, the animals were challenged by injection with 0.05mL of 0.1% dicyclopentadiene and skin reactions graded using the Draize scheme. Mild erythema was seen 24-48 h after administration of this challenge and this was evaluated as a negative response.
Human information
No relevant information
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Non human information
There are no specific animal studies to assess respiratory sensitisation but a wide range of inhalation studies in a number of animal species have shown no evidence of respiratory sensitisation potential.
Human information
Very little information has been reported on the irritation effects of dicyclopentadiene in humans. However, in a study in volunteers to determine the human sensory response to dicyclopentadiene vapour and to determine the odour threshold (Kinkead et al, 1971) there was no evidence of respiratory sensitisation.
Justification for classification or non-classification
Dicyclopentadiene was shown to be non-sensitising in a guideline skin sensitisation study in animals and therefore requires no classification under CLP.
Since there is no evidence for respiratory sensitisation in a range of inhalation studies in various animal species or in the limited documented human exposures, dicyclopentadiene is considered not to warrant classification under CLP.
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