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Diss Factsheets
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EC number: 200-836-8 | CAS number: 75-07-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
1. Literature
According to the literature that was investigated by THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS (SCCNFP) a clear sensitizing potential can not be derived for Acetaldehyde. The SCCNFP presented a modified Cumulative Contact Enhancement Tests (CCET) with positive result and human data that does not justify classification as human sensitizer.
2.Additonal results
In order to assess the cutaneous allergenic potential of acetaldehyde, the Guinea Pig Maximization Test according to OECD 406 was carried out in 30 female guinea pigs. The intradermal induction of sensitisation was performed with 5% dilution of Acetaldehyde in acetone and in an emulsion of Freund's Complete Adjuvant/physiological saline . The epidermal induction of sensitization was conducted under occlusion with acetaldehyde at 50% in acetone. Two weeks after the epidermal induction application the callenge was completed by epidermal application of the test item at 25% in acetone under occlusive dressing. The animal of the control group were induced with acetone and Freund's Complete Adjuvant/physiological saline and callenged similarly to those of the test group. Cutaneous reactions, ie erythema and eschar, as well as oedema formation were evaluated at 24 and 48 hours after the removal of the dressing. Neither the test group nor the control group erythematous reactions were obsered. The positve control group that was treated with the known sensitizer alpha-Hexylcinnamaldehyde did show the expected reaction from slight to severe edemas. Therefore, acetaldehyde is considered not to be a sensitizer under the conditions of the test.
Conlusion
Based on the currently available data acetaldehyde should not be classified as human sensitizer.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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