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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The LC50 was determined to be > 1000 mg/L

Key value for chemical safety assessment

LC50 for freshwater fish:
1 000 mg/L

Additional information

In the key study the acute toxicity of D-Panthenol for fish was estimated by continuous exposure of rainbow trouts for 96 hours, according to the GLP Standard Operation Procedure PSU FT1991. Following an acclimation and adaptation period, groups of ten trouts were exposed under controlled conditions, using a static test system, to three different concentrations of the test compound. As a control, a group of ten fish was exposed to normal city water. Fish were observed daily and behavior and mortality were recorded. Based on the 96-hour acute toxicity study, the NOEC (no observed effect concentration) of D-Panthenol for rainbow trouts (Salmo gairdneri) is > 1000 mg/L.

In a supporting study the short term toxicity to fish was assessed in a study performed in golden orfe equivalent or similar to OECD Guideline 203. Based on the results obtained from testing the EC50 (96 h) was determined to be > 10000 mg/L.