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Physical & Chemical properties

Dissociation constant

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Description of key information

A read across approach was performed with the structural similar substance DL-Panthenol. The dissociation constant of DL-Panthenol was determined to 11.6 at 20 °C.

Key value for chemical safety assessment

pKa at 20°C:
11.6

Additional information

A read across approach was performed with the structural similar substance DL-Panthenol. For justification of read across please refer to the attachment in IUCLID5 section 13. The dissociation of a chemical in aqueous solution is of importance in assessing its impact upon the environment. It governs the form of the test item, which in turn determines its behavior and transport in environmental compartments. It may affect the adsorption of the chemical on soils and sediments as well as uptake into biological cells.

In the present study, the dissociation constant (pKa) of DL-Panthenol in water was determined by titration with 0.01 M sodium hydroxide solution. The dissociation constant was determined to be pKa = 11.6

The pKa value indicates a weak acid and it can be concluded that there is no significant dissociation in the relevant pH range.