Registration Dossier
Registration Dossier
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EC number: 481-740-5 | CAS number: 848301-67-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No studies are available. Hydrocarbons are absorbed through the lung and the gastro-intestinal tract. They are widely distributed and excreted in urine or in exhaled air, depending on volatility. They are metabolised by ω- or ω-1 oxidation to the alcohol and then to the fatty acid. Fatty acids derived from hydrocarbons are likely to enter intermediary metabolism (including β-oxidation) and be excreted in bile urine and exhaled air (as carbon dioxide) (Illing 2006, unpublished report).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - dermal (%):
- 100
Additional information
Toxicokinetics is not specifically required by REACH and the toxicokinetics behaviour derived from available substance data might make further testing unnecessary in terms of predictability of other properties. In accordance with this approach (specified in “Guidance on Information Requirements and Chemical Safety Assessment”, Chapter R7c, Section R7.12.2), the report of Illing (unpublished report, 2006) can be taken into account and allows a qualitative judgement of the toxicokinetic properties of the test substance:
Hydrocarbons are absorbed through the lung and the gastro-intestinal tract. They are widely distributed and excreted in urine or in exhaled air, depending on volatility. They are metabolised by ω- or ω-1 oxidation to the alcohol and then to the fatty acid. Fatty acids derived from hydrocarbons are likely to enter intermediary metabolism (including β-oxidation) and be excreted in bile urine and exhaled air (as carbon dioxide) (Illing 2006, unpublished report).
In addition 'Distillates (Fischer-Tropsch), C8-26 - branched and linear' has a measured log Kow of >6.5 and chemicals with log Kow >5 can pass through the stratum corneum but is limited by low water solubility in their ability to enter the bloodstream. However the irritating /defatting effects are likely to enhance dermal penetration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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