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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

short-term repeated dose toxicity: oral
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
Please refer to the category justification provided in the category object.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Octadecan-1-ol, ethoxylated
EC Number:
EC Name:
Octadecan-1-ol, ethoxylated
Cas Number:
Molecular formula:
not applicable, UVCB

Results and discussion

Effect levels

Key result
Dose descriptor:
Effect level:
1 000 mg/kg bw/day (actual dose received)
Based on:
test mat.
Basis for effect level:
other: No toxicologically relevant effects observed

Target system / organ toxicity

Key result
Critical effects observed:

Any other information on results incl. tables

For a detailed assessment of the repeated dose toxicity of the Alcohol Ethoxylates (AE) category, please refer to the category justification attached to the category object.

Applicant's summary and conclusion

Applying read-across based on grouping of substances (category approach), no toxicologically relevant effects after short-term repeated dose administration and a NOAEL for systemic toxicity ≥ 1000 mg/kg bw/day are predicted for the registered substance.
Executive summary:

The available data on repeated dose toxicity in the 'linear' subgroup of the Alcohol Ethoxylates (AE) category indicates no toxicologically relevant effects for the registered substance. As explained in the category justification, the differences in molecular structure and composition between the registered substance and the members of the AE category are unlikely to lead to differences with respect to short-term repeated dose toxicity.