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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Study period:
1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study without detailed documentation.

Data source

Reference
Reference Type:
publication
Title:
Inhibition of Metabolic Cooperation in Chinese Hamster V79 Cells by Various Organic Solvents and Simple Compounds
Author:
Chen TH, Kavanagh TJ, Chang CC & Trosko JE
Year:
1984
Bibliographic source:
Cell Biology and Toxicology, 1( 1):pp 155-171

Materials and methods

Type of study / information:
Assessment of cytotoxicity and metabolic cooperation
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Assessment of cytotoxicity and metabolic cooperation in Chinese hamster lung fibroblast V79 cells
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-Methyl-2,4-pentanediol

Results and discussion

Any other information on results incl. tables

2 -Methyl-2,4 -pentandiol was positive in the metabolic cooperation assay and a direct correlation between cytotoxic potential and metabolic cooperation inhibiting potential was found.

Applicant's summary and conclusion