Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-659-0 | CAS number: 682-01-9
Endpoint summary
Administrative data
Description of key information
In a skin irritation study conducted to OECD 404 and to GLP (LPT, 2002b), tetrapropyl orthosilicate was not irritating to the skin of rabbits.
In an eye irritation study conducted to OECD 405 and to GLP (LPT, 2002c), tetrapropyl orthosilicate was not irritating to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is one study available for each of skin and eye irritation.Tetrapropyl orthosilicate was not irritating to skin or eyes in reliable studies.
Justification for selection of skin irritation / corrosion endpoint:
The selected study is the only skin irritation study available for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for selection of eye irritation endpoint:
The selected study is the only eye irritation study available for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available data tetrapropyl orthosilicate is not classified for skin or eye irritation under Regulation (EC) No1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
