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Toxicological information

Carcinogenicity

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Description of key information

The carcinogenic potential of dipotassium persulfate was assessed with a read across approach based on data from substances of the Persulfate Category. A study that examined carcinogenicity potential by dermal route was available for diammonium persulfate. Based on the assessment dipotassium persulfate was not considered carcinogenic.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Dipotassium persulfate of the Persulfate Category was not tested for carcinogenicity potential. As all substances of the Persulfate Category share the same anionic persulfate moiety and similar toxicological properties a read across approach was applied for dipotassium persulfate using results of a 51 weeks dermal carcinogenicity study in mice performed with another substance of the Persulfate Category, diammonium persulfate. Based on the results obtained with diammonium persulfate, dipotassium persulfate was considered not carcinogenic when applied to the skin.

Of the Persulfate Category, diammonium persulfate was tested for skin carcinogenicity potential. Based on the obtained results in a 51 week dermal study in mice, diammonium persulfate was not considered to be tumour promoter or a carcinogen when applied to the skin. As all substances of the Persulfate Category share the same anionic persulfate moiety and similar toxicological properties a read across was applied for dipotassium persulfate and disodium persulfate using results obtained with diammonium persulfate. No carcinogenesis potential was assumed for dipotassium persulfate and disodium persulfate.

Justification for classification or non-classification

Substances of the Persulfate Category were not classified and labelled as carcinogenic according to Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP), based on results obtained for substances of the Persulfate Category.