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EC number: 231-781-8 | CAS number: 7727-21-1
The subchronic inhalation toxicity of diammonium persulfate was examined in Sprague-Dawley rats (20/sex/group) at respirable dust concentrations of 0, 5.0, 10.3, and 25 mg/m³. Whole-body exposures were conducted 6 h/day, 5 days/week for 13 weeks. Gravimetric airborne test material samples were taken daily and particle size samples were taken weekly from each exposure chamber for analysis. Ten animals/sex/group were necropsied after 13 wk of exposure, and 5 animals/sex/group were held for 6- and 13-wk recovery periods. Animals were observed for clinical signs. Effects on body weight, food consumption clinical chemistry and haematology, ophthalmologic parameters organ weights, gross lesions, and histopathology were evaluated. There were no exposure-related deaths during the study. Based on these results, the no-observed-adverse-effect level (NOAEC) was 10.3 mg/m³, while the no-observed-effect level (NOEC) for exposure of rats to a dust aerosol of diammonium persulfate was 5.0 mg/m³. Diammonium persulfate revealed in the study respiratory tract irritation properties as irritation of the trachea and bronchi/bronchioles was noted microscopically after 13 weeks of exposure to 25 mg/m³. These lesions had recovered by 6 wk post exposure.
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