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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
1983-03-02 to 1983-03-16
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP study.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report Date:
1983

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
Principles of method if other than guideline:
NA
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): ammonium persulfate
- Physical state: solid, white
- Analytical purity: > 99%

Test animals

Species:
rabbit
Strain:
other: Albino - White Russian
Details on test animals and environmental conditions:
TEST ANIMALS
- Source:
- Age at study initiation: 4-5 months
- Weight at study initiation: 2.0 - 2.2 kg
- Housing: individually in stainless steel cages
- Diet (e.g. ad libitum): standardised test animal feed, Altromin
- Water (e.g. ad libitum): ad libitum



ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 °C ± 1°C
- Humidity (%): 50 - 60 %
- Photoperiod (hrs dark / hrs light): 12 hours light/ 12 hours dark


Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
no
Amount / concentration applied:
0.5 g of the test substance.
Duration of treatment / exposure:
4 hours
Observation period:
1, 24, 48, 72 h
Number of animals:
3
Details on study design:
NA

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible within: 24 h
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible within: 24 h
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible within: 24 h
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible within: 24 h
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24, 48, 72 h
Score:
0.33
Max. score:
4
Reversibility:
fully reversible within: 48 h
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible within: 48 h
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible within: 48 h
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible within: 48 h
Irritant / corrosive response data:
No systemic-toxic effects occurred after treatment with the test material. All animals remained healthy throughout the study.
Other effects:
NA

Any other information on results incl. tables

No remarks

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Under conditions of the study, diammonium persulfate revealed no skin irritating properties.
Executive summary:

Diammonium persulfate was applied in a single dose of 0.5 g diammonium persulfate to intact skin of albino rabbits. One hour after the end of the exposure period the three rabbits had slight erythema which disappeared at the time of the study observation time points after 24 and 48 hours. None of the animals reach an average of erythema or oedema score of equal or above 2. The highest score (oedema score) was 0.33 obtained in one of the three rabbits. Under the conditions of the study diammonium persulfate was not considered irritating to skin. Additionally no systemic-toxic effects occur after treatment with the test material. All animals remained healthy throughout the study.