Registration Dossier

Administrative data

Description of key information

Dipotassium persulfate was tested for skin and eye irritation. In the skin irritation study, dipotassium persulfate was found not irritating to the skin. In the eye irritation study, dipotassium persulfate was found to be slightly irritating to the rabbit eye. Human case studies indicated that dipotassium persulfate causes eye irritation. Additional studies were available for substances of the Persulfate Category, diammonium persulfate and disodium persulfate. Using a read across approach from data available for diammonium persulfate, dipotassium persulfate was considered a respiratory tract irritant. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

All substances of the Persulfate category share the same anionic persulfate moiety and similar toxicological properties. Diammonium persulfate, dipotassium persulfate and disodium persulfate were tested in animal studies for skin irritation/corrosion and eye irritation and diammonium persulfate was examined for respiratory irritation in a subchronic inhalation toxicity study. Additionally, human data was available for dipotassium persulfate and diammonium persulfate. Dipotassium persulfate was tested for skin irritation in rabbits. The test material was applied in a single application to the intact and abraded skin of six rabbits each. No signs of irritation/corrosion were observed. In contrast to animal studies, human case studies revealed skin sensitisation properties. Dipotassium persulfate was tested for eye irritation/corrosion in rabbits. Slight irritation effects, which were fully reversible within 24 hours were observed in two of the eight test animals. In humans, one case of corneal burns from dipotassium persulfate was reported and irritant effects of persulfates may cause pain in the eyes with conjunctivitis. Using a read across approach from data available for diammonium persulfate, dipotassium persulfate was considered a respiratory tract irritant. For the Persulfate Category worst-case results were considered for safety assessment: Skin irritation: irritating Eye irritation: irritating Respiratory irritation: irritating


Effects on eye irritation: irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Based on animal test results and human case study data, substances of the Persulfate Category were classified and labelled Xi, R 36/37/38 (irritating to eyes, respiratory system and skin) according to Directive 67/548/EEC (DSD) and eye irritant, cat. 2 H319 (causes serious eye irritation), skin irritant cat. 2 H315 (causes skin irritation) and respiratory tract irritant cat. 3 STOT SE. 3 H335 (causes respiratory tract irritation) according to Regulation (EC) No 1272/2008.