Registration Dossier

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Absorption of ethereal oils and substances contained in them through the skin
Author:
Meyer F and Meyer E
Year:
1959
Bibliographic source:
Arzneimittel-Forschung, 9, 516-519.
Reference Type:
secondary source
Title:
Fragrance Raw Materials Monographs
Author:
Opdyke DLJ
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Vol. 12: 881-882

Materials and methods

Principles of method if other than guideline:
skin absorption study

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Sex:
male

Administration / exposure

Type of coverage:
not specified
Duration of exposure:
2 h
No. of animals per group:
total 230 mice

Results and discussion

Any other information on results incl. tables

No absorption was reported.

Applicant's summary and conclusion