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EC number: 206-156-8 | CAS number: 304-59-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Tartaric acid can be considered as a non-sensitiser as determined by a GLP conducted OECD test guideline 429. This information is fully relevant towards read across to potassium sodium tartrate as the
salt dissociates in solution into the tartrate group, yielding an identical active organic group in solution. This result is supported by the prediction obtained using the validated QSAR MultiCase model (A33) for
the potassium sodium tartrate.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although reported GLP the information originated from a detailed review study that refers to an unpublished study. Thereby full details are nonot available for examination.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Vehicle:
- dimethylformamide
- Concentration:
- 25 microliters of test material. According to OECD Guideline.
Concentrations used: 5.0, 10.0 and 25% tartaric acid - No. of animals per dose:
- According to OECD Guideline. No further detail reported in review.
- Parameter:
- SI
- Remarks on result:
- other: At 5.0 %: 1.0 At 10.0%: 0.9 At 25.0%: 1.5 LLNA EC3% - Not calculated
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Tartaric acid can be considered as a non-sentitiser as determined by OECD test guideloin 429. This information is fully relevant towards read across to potassium sodium tartrate as the salt dissociates in solution into the tartrate group, yielding an identical active organic group in solution.
- Executive summary:
Tartaric acid can be considered as a non-sentitiser as determined by OECD test guideline 429. This information is fully relevant towards read across to potassium sodium tartrate as the salt dissociates in solution into the tartrate group, yielding an identical active organic group in solution.
- Endpoint:
- skin sensitisation, other
- Remarks:
- Skin Sensitization, MultiCASE commercial model (A33)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- In accordance with section 1 of REACH Annex XI, testing is not scientifically neccessary based on use of qualitative or quantitative structure - activity relationship (QSAR).
- Guideline:
- other: REACH guidance on QSARs R.6, May/July 2008
- Principles of method if other than guideline:
- Fragment-based statistical system used in the QSAR model.
- Specific details on test material used for the study:
- Data reported for the anhydrous salt.
SMILES: [Na]OC(=O)C(O)C(O)C(=O)OK - Parameter:
- other: Data predicted from QSAR: data from GPMT or human experiences.
- Value:
- ca. -1
- Remarks on result:
- no indication of skin sensitisation based on QSAR/QSPR prediction
- Interpretation of results:
- other: not sensitising
- Conclusions:
- Based on the prediction result indicated above the substance potassium tartrate (SMILES: [Na]OC(=O)C(O)C(O)C(=O)OK) has not to be classified for Sensitisation.
Referenceopen allclose all
Endpoint: Skin
Value=-1 (negative)
Training set = 1033
LGO (10%) gave: Sensitivity = 69 -89 %; Specificity = 89 -94 %; Concordance = 82 -89 %; Applicability of domain = 0.58
Data from GPMT or human experiences.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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