Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-156-8 | CAS number: 304-59-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- RISCHI PER LA SALUTE DEGLI OPERAI DI UNA FABBRICA DI ACIDO TARTARICO
- Author:
- M. BARSOTTI et al.
- Year:
- 1 954
- Bibliographic source:
- La medicina del lavoro.1954;45(4);239-249
Materials and methods
- Study type:
- medical monitoring
- Endpoint addressed:
- acute toxicity: inhalation
- skin irritation / corrosion
- other: urine analysis... (see attached file)
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (+)-tartaric acid
- EC Number:
- 201-766-0
- EC Name:
- (+)-tartaric acid
- Cas Number:
- 87-69-4
- Molecular formula:
- C4H6O6
- IUPAC Name:
- tartaric acid
- Test material form:
- not specified
- Details on test material:
- No details on test material identity are available.
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- A hygienic-sanitary study has been carried out on 156 workers in a factory of tartaric acid and its derivates.
Results and discussion
- Results:
- The most frequent symptoms in the exposed group is represented by:
- Erosion of the masticatory surfaces of the incisive and canine teeth
- Cutaneous ulcers
- Reddening and edema of the ungual vallum
- Ulcers and hyperacid gastroduodenitis
- Urine analysis
Any other information on results incl. tables
Pathological events in workers involved in the production of tartaric acid.
Section |
N° Workers |
Erosion of the masticatory surfaces of the incisive and canine teeth |
Cutaneous ulcers - Reddening and edema of the ungual vallum |
Ulcers and hyperacid gastroduodenitis |
Feverish attack |
Warehouse |
24 |
8 (33.3%) |
- |
- |
- |
Roasting |
9 |
2 (22.2%) |
- |
- |
24 |
Manufacturing |
93 |
12 (12.9%) |
2(2.1%) |
7(7.6) |
- |
Centrifuge |
18 |
3 (16.6%) |
4(22.2%) |
2(11.1) |
- |
Shipping Warehouse |
12 |
5 (41.4%) |
3(25%) |
7(58.3) |
|
|
156 |
30 (19.3%) |
9(5.8%) |
16(10.2%) |
24 |
Applicant's summary and conclusion
- Conclusions:
- Skin ulcers was frequent in workers exposed to direct contact with tartaric acid pure or concentrated.
- Executive summary:
30 workers (19.3%) showed modest signs of erosion of the masticatory surfaces of the incisive and canine teeth, with all the features and frequency equal to those found in other workers of the same age and social conditions, not exposed to tartaric acid. The formation of skin ulcers was frequent. These disorders are found only in workers exposed to direct contact with tartaric acid pure or concentrated. In these same workers are frequent gastric ulcers and hyperacid gastroduodenitis. Involved workers in the grinding of raw materials showed feverish attack at the end of the work shift, lasting a few hours, without alteration of the terms and conditions. These disturbances are due to inhalation of powder of pure tartaric acid, which contains magnesium oxide, with pathogenesis similar to the fever of the smelters. Tartaric acid is eliminated even in doses of 450/600 mg/L, without causing visible damage to the renal parenchyma.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.