Potassium sodium tartrate

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.

Data source

Reference

Reference Type:

publication

Title:

Indagine su un gruppo di soggetti con esposizione professionale ad acido tartarico

Author:

Moscato et al.

Year:

1983

Bibliographic source:

ltal. Med. Lav. 1983; 5: 193-198.

Materials and methods

Study type:

medical monitoring

Endpoint addressed:

skin irritation / corrosion

eye irritation

respiratory irritation

repeated dose toxicity: oral

other: spirometry... (see attached file)

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

no data

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

(+)-tartaric acid

EC Number:

201-766-0

EC Name:

(+)-tartaric acid

Cas Number:

87-69-4

Molecular formula:

C4H6O6

IUPAC Name:

(2R,3R)-2,3-dihydroxybutanedioic acid

Test material form:

not specified

Details on test material:

No details on test material identity are available.

Method

Type of population:

occupational

Ethical approval:

not specified

Details on study design:

Evaluation of human workers occupationally-exposed to tartaric acid.
The study reports the results of un investigation carried out in a factory producing tartaric acid in order to evaluate the effects of occupational exposure to tartaric acid. A group of 74 subjects exposed to the acid and a group of 30 subjects not exposed, as a means of control, were submitted to unamnestic questionnaire.

Results and discussion

Results:

The most frequent symptoms in the exposed group is represented by:
- Nasal obstruction
- itch and sneeze
- Hypo-anosmia
- Nosebleed
- Sore throat
- Dysphonia
- Skin irritation
- Ulceration
The investigations carried out have shown in the group of subjects exposed to tartaric acid the presence of lesions cutaneous and nasopharyngeal, that develop with mode that appear with different and significantly greater frequency compared to the control group. The skin lesions are localized, for the most part the hands and depend from direct contact with the powder.

Any other information on results incl. tables

Responses to the questionnaires

Examined group	nasopharyngeal symptoms	skin disorder	eye disorder	gastrointestinal disorder	tooth disorder
exposed	20* (45.45%)	34* (77.3%)	23 (52.3%)	21 (47.7%)	27 (61.4%)
control group not exposed	2 (6.7%)	6  (20%)	8 (26.7%)	13 (43.3%)	11 (36.7%)

* p <0.001 data statistically significant.

Applicant's summary and conclusion

Conclusions:

Data show a higher prevalence of oropharyngeal and cutaneous lesions in the exposed subjects, while no difference between the two groups was found for dental, bronchial and gastric lesions.

Executive summary:

Data show a higher prevalence of oropharyngeal and cutaneous lesions in the exposed subjects, while no difference between the two groups was found for dental, bronchial and gastric lesions.