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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.

Data source

Reference
Reference Type:
publication
Title:
RISCHI PER LA SALUTE DEGLI OPERAI DI UNA FABBRICA DI ACIDO TARTARICO
Author:
M. BARSOTTI et al.
Year:
1954
Bibliographic source:
La medicina del lavoro.1954;45(4);239-249

Materials and methods

Study type:
medical monitoring
Endpoint addressed:
acute toxicity: inhalation
skin irritation / corrosion
other: urine analysis... (see attached file)
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
No details on test material identity are available.

Method

Type of population:
occupational
Ethical approval:
not specified
Details on study design:
A hygienic-sanitary study has been carried out on 156 workers in a factory of tartaric acid and its derivates.

Results and discussion

Results:
The most frequent symptoms in the exposed group is represented by:
- Erosion of the masticatory surfaces of the incisive and canine teeth
- Cutaneous ulcers
- Reddening and edema of the ungual vallum
- Ulcers and hyperacid gastroduodenitis
- Urine analysis

Any other information on results incl. tables

Pathological events in workers involved in the production of tartaric acid.

Section

N° Workers

Erosion of the masticatory surfaces of the incisive and canine teeth

 Cutaneous ulcers - 

Reddening and edema of the ungual vallum

 Ulcers and hyperacid gastroduodenitis

Feverish attack

Warehouse

24

8 (33.3%)

 -

 -

-

Roasting

9

2 (22.2%)

 -

 -

24

Manufacturing

93

12 (12.9%)

2(2.1%)

7(7.6)

 -

Centrifuge

18

3 (16.6%)

4(22.2%)

2(11.1)

 -

Shipping Warehouse

12

5 (41.4%)

3(25%)

7(58.3)

 

 

156

30 (19.3%)

9(5.8%)

16(10.2%)

24

Applicant's summary and conclusion

Conclusions:
Skin ulcers was frequent in workers exposed to direct contact with tartaric acid pure or concentrated.
Executive summary:

30 workers (19.3%) showed modest signs of erosion of the masticatory surfaces of the incisive and canine teeth, with all the features and frequency equal to those found in other workers of the same age and social conditions, not exposed to tartaric acid. The formation of skin ulcers was frequent. These disorders are found only in workers exposed to direct contact with tartaric acid pure or concentrated. In these same workers are frequent gastric ulcers and hyperacid gastroduodenitis. Involved workers in the grinding of raw materials showed feverish attack at the end of the work shift, lasting a few hours, without alteration of the terms and conditions. These disturbances are due to inhalation of powder of pure tartaric acid, which contains magnesium oxide, with pathogenesis similar to the fever of the smelters. Tartaric acid is eliminated even in doses of 450/600 mg/L, without causing visible damage to the renal parenchyma.