Registration Dossier
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EC number: 206-156-8 | CAS number: 304-59-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is found to be readily biodegradable and the applied test concentrations are in the range of concentrations that can be expected in the influent of a sewage treatment plant
- Justification for type of information:
- Study on the test substance is not necessary as valid conclusions regarding bacterial toxicity can be derived from RSS for the ready biodegradability test in this dossier.
- Reason / purpose:
- reference to same study
- GLP compliance:
- yes
- Validity criteria fulfilled:
- yes
- Conclusions:
- Results from a 14 d ready biodegradability study using a bacterial innoculum derived from sludge obtained from municipal waste water treatment plants in Japan, as well as from natural soil and waters, indicats that the substance is readily degradable. According to the data presented (see RSS) BOD at 14 days in the three triplicates containing 100 mg/L disodium tartrate exhibited a far greater demand than the control blank, containing sludge and dilution medium (all samples containing slude at 30 mg/L). Thereby it can be concluded that no effect upon respiratory activity of the bacteria was caused after 14d exposure by the amalogu disodium tartrate.
- Executive summary:
Results from a 14 d ready biodegradability study using a bacterial innoculum derived from sludge obtained from municipal waste water treatment plants in Japan, as well as from natural soil and waters, indicats that the substance is readily degradable. According to the data presented (see RSS) BOD at 14 days in the three triplicates containing 100 mg/L disodium tartrate exhibited a far greater demand than the control blank, containing sludge and dilution medium (all samples containing slude at 30 mg/L). Thereby it can be concluded that no effect upon respiratory activity of the bacteria was caused after 14d exposure by the amalogu disodium tartrate. Thereby, considering the only effect detected is stimulation of respiration (the tartrate is degraded as a substrate for respiration of the sludge), a NOEC value of 100 mg/L fpr analogue substance disodium tartrate can be provided.
- Endpoint:
- toxicity to microorganisms
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only brief summary reported in IUCLID 4 report for Citric acid.
- Qualifier:
- no guideline followed
- Guideline:
- other: Not cited
- GLP compliance:
- not specified
- Test organisms (species):
- Pseudomonas putida
- Test type:
- not specified
- Water media type:
- not specified
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Validity criteria fulfilled:
- not specified
- Executive summary:
Toxicity study reported for effect of citric acid on Pseudomonas putida in IUCLID 4 dataset. Data insufficient to assess validity of EC50 reported as > 10 g/L, but overall is coherent with metabolic and other toxicological data which support to low toxicity and easy biodegradability of short chained dicarboxyllic acids by bacterial cultures.
Referenceopen allclose all
Description of key information
According to the data presented (see RSS) BOD at 14 days in the three triplicates containing 100 mg/L disodium tartrate exhibited a far greater demand than the control blank, containing sludge and dilution medium (all samples containing slude at 30 mg/L). Thereby it can be concluded that no effect upon respiratory activity of the bacteria was caused after 14d exposure by the analogue disodium tartrate.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Results from a 14 d ready biodegradability study using a bacterial innoculum derived from sludge obtained from municipal waste water
treatment plants in Japan, as well as from natural soil and waters, indicats that the substance is readily degradable. According to the data
presented (see RSS) BOD at 14 days in the three triplicates containing 100 mg/L disodium tartrate exhibited a far greater demand than
the control blank, containing sludge and dilution medium (all samples containing slude at 30 mg/L). Thereby it can be concluded that no
effect upon respiratory activity of the bacteria was caused after 14d exposure by the analogue disodium tartrate. Thereby, considering the
only effect detected is stimulation of respiration (the tartrate is degraded as a substrate for respiration of the sludge), a NOEC value of
100 mg/L fpr analogue substance disodium tartrate can be provided.
In addition, a toxicity study was identified reporting effects of citric acid on Pseudomonas putida in IUCLID 4 dataset. Data insufficient to
assess validity of EC50 reported as > 10 g/L, but overall is coherent with metabolic and other toxicological data which support to low
toxicity and easy biodegradability of short chained dicarboxyllic acids by bacterial cultures.
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